Characters
Yasuke (弥助)
Voiced by: Jun Soejima (Japanese); LaKeith Stanfield (English)
Once a servant of Jesuits named Eusebio Ibrahimo Baloi and originally of Yao descent, he was named Yasuke upon becoming a samurai under Oda Nobunaga, after which his skill and honor earned much of his lord's favor, despite the discrimination for his skin and distrust for his foreign origin. After serving as Nobunaga's kaishakunin following his defeat at Honnō-ji Temple, he escaped his bondage under the Jesuits and became a recluse working as a boatman ferrying people along the river he resides on. After 20 years in hiding, he reluctantly joins Saki on a quest after the pair cross paths against Abraham and the servants of the Yami no Daimyō.
Oda Nobunaga (織田 信長)
Voiced by: Takehiro Hira (Japanese and English)
The historic warlord of Japan, that nearly succeeded in united Japan under his crest. Just as historically, Nobunaga scoffed at traditions to progress Japan under his rule, even bringing in Yasuke as a retainer. Nobunaga was also unabashed by his romantic love for Ranmaru.
Saki (咲希)
Voiced by: Kiko Tamura (Japanese); Maya Tanida (English)
Ichika's adopted daughter, rescued from Abraham as an infant. She possesses incredible mystical powers with the potential to rival the Yami no Daimyō as the villain's natural counterbalance.
Natsumaru (夏丸)
Voiced by: Fusako Urabe (Japanese); Ming-Na Wen (English)
Described as an onna bugeisha, a lady samurai for Nobunaga, she befriends Yasuke and share a common bond of being considered outsiders by others in Nobunaga's ranks. Natsumaru was revealed to be a member of the Iga clan and also a spy for Hattori Hanzo within Nobunaga's ranks. Despite having an attraction for Yasuke, he discovers her secret and regretfully kills her amid the battle with Hanzo's army.
Ichika (一華)
Voiced by: Rie Tanaka (Japanese); Gwendoline Yeo (English)
A singer at an inn where she meets Yasuke, hiring him to take her and Saki to a doctor upriver.
Morisuke (守助)
Voiced by: Yu Kamio (Japanese); Paul Nakauchi (English)
The doctor who exclusively treats and trains Saki, as he shares similar powers. He was once a samurai in Nobunaga's forces, serving alongside Yasuke. He runs a school mentoring psychics and sees Saki as the chosen one to end the Yami no Daimyō.
Ishikawa (イシカワ)
Voiced by: Eri Kitamura (Japanese); Dia Frampton (English)
An assassin wielding a giant scythe and other knives, working for Abraham to fetch Saki. After aiding Yasuke and Morisuke, she dies when the Daimyō's personal army comes for Saki.
Haruto (ハルト)
Voiced by: Shunsuke Kubozuka (Japanese); Darren Criss (English)
A self-aware weaponized robot with humorous tendencies, working for Abraham to fetch Saki. After Ishikawa's death, he kamikaze strikes the Daimyō's forces in revenge.
Nikita (ニキータ)
Voiced by: Hiroki Nanami (Japanese); Julie Marcus (English)
A Russian Werebear assassin working for Abraham to fetch Saki. After his death, she stops hunting Saki and helps Yasuke at Morisuke's temple. She sacrifices herself to buy time for Morisuke's forces to retreat, and for Yasuke to take Saki elsewhere.
Achoja (アチョウジャ, Achouja)
Voiced by: Kenji Kitamura (Japanese); William Christopher Stephens (English)
An African shaman originally from the Kingdom of Benin, he is hired by Abraham to capture Yasuke to find Saki. After Abraham's death, he and his party take their pay and he also develops a warrior's respect with Yasuke. He aids Morisuke's efforts against a monster of the Daimyō's and is richly rewarded, the only member of his group to survive after the end battle.
Abraham (アブラハム, Aburahamu)
Voiced by: Shigeru Ushiyama (Japanese); Dan Donohue (English)
A priest with mutant powers in service to the Catholic Church, aiming to take Saki to Europe and conquer the continent, then take the Church as its new leader. Yasuke and Saki kill him after both are captured by his hired assassins.
Yami no Daimyō (闇の大名)
Voiced by: Yoshiko Sakakibara (Japanese); Amy Hill (English)
The dark mage who conquered a swath of Japan, who seeks to take Saki's power for herself, seeing her as a natural threat. In the last episode she was identified as Hojo Masako, a noble from Kamakura shogunate.