Yakiv Yukhymovych Lyzohub (; , Yakov Yefimovich Lizogub) was a military and political figure of the Cossack Hetmanate and a member of a well known Cossacks family of Lyzohub.
He was born in a family of Chernihiv Colonel Yukhym Yakovych Lyzohub and Lyubov Petrivna Doroshenko. Yakiv Lyzohub was a grandson of Hetman Petro Doroshenko. He graduated from the Kyiv-Mohyla Academy that in the 19th century was transformed into the Kyiv Theological Academy on the order of the Russian Holy Synod.
In 1713-28 Lyzohub was a Bunchuk General.
In 1723-24 he along with Colonel Danylo Apostol and Yesavul General Vasyl Zhurakovsky was imprisoned by Peter the Great in the Peter and Paul Fortress as a members of Pavlo Polubotok's party. After the release Lyzohub was forced to live for sometime in Saint Petersburg.
