2011–present
In 2011, McLendon-Covey starred in the financially successful and critically lauded comedy film Bridesmaids with Kristen Wiig, Maya Rudolph, Rose Byrne, Melissa McCarthy, and Ellie Kemper. Beginning in July that same year, she began starring in national TV ads for a new campaign by Hillshire Farm. From 2010 to 2013, she had a recurring role on the CBS sitcom Rules of Engagement. She also had guest-starring roles in Fox's short-lived sitcom I Hate My Teenage Daughter, TV Land's Hot in Cleveland, and ABC's Modern Family.
McLendon-Covey appeared in the 2012 romantic comedy What to Expect When You're Expecting, directed by Kirk Jones, and Steven Soderbergh's film Magic Mike. She had roles in the Christmas comedy movie A White Trash Christmas about a mom visited by three ghosts intent on showing her a path to a brighter future, and in the comedy-drama film The Breakup Girl directed by Academy Award-nominated and Emmy-winning Stacy Sherman about three estranged sisters dealing with the death of their father.
In February 2012, McLendon-Covey was cast in the HBO comedy pilot The Viagra Diaries, created by Sex and the City creator and executive producer Darren Star, but when Goldie Hawn exited the pilot, McLendon-Covey also left the show. After she received five offers, she won the female lead role on ABC's comedy pilot Only Fools And Horses. She also played one of the leads in Tyler Perry's film The Single Moms Club (2014). Also in 2014, she starred in A Merry Friggin' Christmas as Robin Williams' character's daughter, Blended, as Drew Barrymore's character's best friend, and Think Like a Man Too.
In January 2013, McLendon-Covey was cast in the lead role of the ABC comedy series The Goldbergs, created by Adam F. Goldberg. Her portrayal of the character received critical praise, and she was nominated for a Critics' Choice Television Award for Best Actress in a Comedy Series in 2014. The series lasted ten years and 229 episodes were produced. She also served as a producer and later as an executive producer of the series.
In 2015, McLendon-Covey co-starred opposite Sally Field in the comedy-drama film Hello, My Name Is Doris. Also that year, McLendon-Covey hosted ABC reality comedy series Repeat After Me, produced by Ellen DeGeneres. In 2016, she played the female leading role opposite Nicolas Cage in the comedy film Army of One, directed by Larry Charles.
McLendon-Covey had a dramatic role as Mark Felt's secretary Carol Tschudy in the political thriller film Mark Felt: The Man Who Brought Down the White House (2017), directed by Peter Landesman. She later played a leading role in the independent drama film Blush that premiered at the 2019 Sundance Film Festival. She starred in the 2018 horror comedy Goosebumps 2: Haunted Halloween and co-starred opposite Taraji P. Henson in the 2019 romantic comedy What Men Want. Since 2018, she has played the voice role of Nancy Green in the Disney Channel animated series Big City Greens. In 2020, she continued appearing in a dramatic roles co-starring opposite Tessa Thompson in Sylvie's Love. In 2020, McLendon-Covey reunited with Bridesmaids co-stars Kristen Wiig and Annie Mumolo in the comedy film Barb and Star Go to Vista Del Mar.
From April 2020 to July 2022, McLendon-Covey co-hosted the pop culture podcast Generation Ripe with surfographer/photo art director and producer Dfernando Zaremba. The podcast's audience was teenagers over 40 and featured interviews with guests from all realms of the entertainment industry and the arts. Also in 2020, McLendon-Covey returned for the seventh season of Reno 911! which was aired on Quibi. In 2021, the movie Reno 911! The Hunt for QAnon was released on Paramount+. The eighth season of the series, now titled Reno 911!: Defunded, premiered on The Roku Channel in February 2022. She co-starred with Owen Wilson in the comedy-drama film Paint, it was released on April 7, 2023.
In 2023, McLendon-Covey played Vicky White in the Lifetime movie Bad Romance: The Vicky White Story based on the manhunt for escaped inmate Casey White and Lauderdale County jailer Vicky White.
McLendon-Covey currently stars on NBC's hit comedy, St. Denis Medical. The show was recently renewed for a third season.