Second Trump administration
In January 2025, it was reported that a CDC official had ordered all CDC staff to stop working with the World Health Organization. Around January 31, 2025, several CDC websites, pages, and datasets related to HIV and STI prevention, LGBT and youth health became unavailable for viewing after the agency was ordered to comply with Donald Trump's executive order to remove all material of "diversity, equity, and inclusion" and "gender identity". Also in January 2025, due to a pause in communications imposed by the second Trump administration at federal health agencies, publication of the Morbidity and Mortality Weekly Report (MMWR) was halted, the first time that had happened since its inception in 1960. The president of the Infectious Diseases Society of America (IDSA) called the pause in publication a "disaster." Attempts to halt publication had been made by the first Trump administration after MMWR published information about COVID-19 that "conflicted with messaging from the White House." The pause in communications also caused the cancellation of a meeting between the CDC and IDSA about threats to public health regarding the H5N1 influenza virus.
On February 1, 2025, the CDC ordered its scientists to retract any not yet published research they had produced which included any of the following banned terms: "Gender, transgender, pregnant person, pregnant people, LGBT, transsexual, non-binary, nonbinary, assigned male at birth, assigned female at birth, biologically male, biologically female". Larry Gostin, director of the World Health Organization Center on Global Health Law, said that the directive amounted to censorship of not only government employees, but private citizens as well. For example, if the lead author of a submitted paper works for the CDC and withdraws their name from the submission, that kills the submission even if coauthors who are private scientists remain on it. Other censored topics include DEI, climate change, and HIV.
Following extensive public backlash, some, but not all, of the removed pages were reinstated. The CDC's censorship led to many researchers and journalists to preserve databases themselves, with many removed articles being uploaded to archival sites such as the Internet Archive.
On February 4, Doctors for America filed a federal lawsuit against the CDC, Food and Drug Administration, and Department of Health and Human Services, asking the removed websites to be put back online. On February 11, a judge ordered removed pages to be restored temporarily while the suit is being considered, citing doctors who said the removed materials were "vital for real-time clinical decision-making".
On February 14, 2025, around 1,300 CDC employees were laid off by the administration, which included all first-year officers of the Epidemic Intelligence Service. The cuts also terminated 16 of the 24 Laboratory Leadership Service program fellows, a program designed for early-career lab scientists to address laboratory testing shortcomings of the CDC. In the following month, the Trump administration quietly withdrew its CDC director nominee, Dave Weldon, just minutes before his scheduled Senate confirmation hearing on March 13.
In April 2025, it was reported that among the reductions is the elimination of the Freedom of Information Act team, the Division of Violence Prevention, laboratories involved in testing for antibiotic resistance, and the team responsible for determining recalls of hazardous infant products. Additional cuts affect the technology branch of the Center for Forecasting and Outbreak Analytics, which includes software engineers and computer scientists supporting the centre established during the COVID-19 pandemic to improve disease outbreak prediction.
In August 2025, over 600 CDC employees were laid off and a number of programs completely dismantled, including "[m]aternal and child health services, oral health programs, and the CDC's long-running Violence Against Children and Youth Surveys (VACS)." Experts have criticized the mass layoffs under Secretary of Health and Human Services Robert F. Kennedy Jr. for creating dangerous gaps in public health. VACS, for instance, has played an essential role in gathering high-quality, actionable data used to assess and mitigate violent harm against children, with such harm being estimated as affecting half of all children worldwide.
In August 2026 Senate confirmation hearings, Dr. Erica Schwartz stated that "abortion surveillance" would be a "critical focus" for the CDC.
Later that month, Schwartz challenged two reported measles deaths in Pennsylvania.
On August 8, 2025, 30-year-old Patrick Joseph White of Kennesaw, Georgia, attacked the CDC's Roybal Campus in Atlanta, Georgia. White attempted to enter the headquarters, but was thwarted by security. White then drove across the street to a CVS Pharmacy where he barricaded himself inside on the second floor, and fired at the campus with a rifle, striking four CDC buildings on multiple floors over 180 times, breaking about 150 windows and piercing some of the blast-resistant windows; authorities recovered more than 500 shell casings and five firearms after the shooting. 33-year-old David Rose, a DeKalb County Police Department officer, was fatally wounded by White as he arrived on the scene. Officers entered the pharmacy and found White dead from a self-inflicted gunshot wound.
White is believed to have been motivated by distrust in vaccines, and believed the COVID-19 vaccine had made him depressed and suicidal. He had reached out for mental health assistance for weeks before the attack. Fired But Fighting, a group of laid-off CDC employees, blamed the attack on the anti-vaccine rhetoric of members of the Trump administration, saying that Secretary of Health and Human Services, Robert F. Kennedy Jr., "is directly responsible for the villainization of CDC's workforce through his continuous lies about science and vaccine safety". A union representing CDC employees called on both the CDC and the leadership of the Department of Health and Human Services to denounce vaccine misinformation, and said that the attack was a result of compounding misinformation and obloquy towards science and health officials. While Kennedy Jr. had reached out to CDC staff and said "no one should face violence while working to protect the health of others", Jerome Adams, a former surgeon general, described Kennedy Jr.'s response as "tepid" and that Kennedy Jr. must do more given his past "inflammatory rhetoric". On August 11, Kennedy Jr. toured the Roybal Campus with deputy secretary Jim O'Neill and CDC director Susan Monarez, but did not speak with the media during the visit, although he did meet privately with Rose's widow. A day later, in an interview with Scripps News, when Kennedy Jr. was asked if he had a message for CDC employees concerned about the consequences of misinformation about vaccines, he said political violence was "wrong" and claimed not enough was known about White's motives yet to draw conclusions before criticizing the government's previous vaccination efforts as "overreaching" and that the government had said "things that are not always true" in order to get people vaccinated. Trump did not respond to the shooting of the police officer.
White's father spoke in an interview with WANF, saying that he and his wife were watching a cable television network in their Kennesaw home when the phone rang. He picked up the phone and attempted to have a normal conversation with his son. White spoke to his father, "I'm gonna shoot up the CDC", before hanging up afterward. The couple immediately changed their channel to one of the Atlanta stations, where his father saw the unmistakable image of his car at the scene.
On May 14, 2025, HHS Secretary Robert F. Kennedy Jr. stated that lawyer Matthew Buzzelli was acting CDC director, though it was not listed on the CDC website.
In June 2025, Kennedy fired all 17 members of the Advisory Committee on Immunization Practices (ACIP) and—with one exception—appointed members who are either anti-vaccine activists or who lack expertise in vaccines.
Susan Monarez was confirmed as CDC head on July 31, 2025, but on August 27, it was announced on X (formerly Twitter) that she had been fired. Monarez disputed the legality of the firing, as it had not been carried out by the president, and it had been falsely reported that she had resigned. The president later officially carried out the firing. Monarez was fired after refusing to rubber stamp what were expected to be unscientific recommendations from ACIP and to fire senior staff vaccine experts. The next day, the Trump administration announced the selection of Deputy Secretary of Health and Human Services Jim O'Neill as a replacement.
Following news of Monarez's ouster, at least four other CDC senior officials announced their resignations:
Debra Houry, Chief Medical Officer
Demetre Daskalakis, Director of the National Center for Immunization and Respiratory Diseases
Daniel Jernigan, Director of the National Center for Emerging and Zoonotic Infectious Diseases
Jennifer Layden, Director of the Office of Public Health Data, Surveillance, and Technology, which contains the National Center for Health Statistics
Dozens of CDC employees walked out of headquarters and protested in support of Monarez and the departing officials.
In November 2025 it was announced that primate research at CDC is due to end.