San Antonio Spurs (2010–2015)
On July 12, 2010, Splitter signed a contract with the San Antonio Spurs. The deal was believed to be worth $11 million over three years.
He earned his first start of his NBA career on March 19, against the Charlotte Bobcats, in place of the injured Tim Duncan. In this game, Splitter recorded eight points and six rebounds.
On February 8, 2012, Splitter and teammate Kawhi Leonard, were selected to play in the 2012 Rising Stars Challenge. On February 17, it was revealed that both Splitter and Leonard would be teammates for Team Chuck. However, due to an injury, he was released from Team Chuck and was replaced by Derrick Favors.
On May 29, 2012, in Game 2 of the Western Conference Finals, Oklahoma City Thunder head coach Scott Brooks attempted to slow San Antonio's offense through continually fouling Splitter, sending him to the free throw line with the "Hack-a-Shaq" strategy.
He played his most productive season with the Spurs in 2012–13, averaging 10.3 points and 6.4 rebounds per game, while playing all but the final game of the regular season. He started 58 games, as the Spurs finished the West as the two-seed, behind the Oklahoma City Thunder. The Spurs would advance to the 2013 NBA Finals, only to lose to the Miami Heat in seven games, as Miami won their second straight NBA championship.
On July 13, 2013, he re-signed with the Spurs. On June 15, 2014, Splitter won his first NBA championship, after the Spurs defeated the Miami Heat, 4 games to 1 in the 2014 NBA Finals.
After missing 20 out of the first 21 games of the 2014–15 season with a back injury, Splitter played out the rest of the season, until missing the final six games of the regular season, with a calf injury. He returned for the playoffs, but the Spurs were knocked out in the first round by the Los Angeles Clippers, in seven games.