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Tim Allen as Scott Calvin / Santa Claus: A former successful businessman who became Santa Claus in 1994 and chose to remain in the role out of the goodness of his heart. After almost thirty years, Calvin believes that he is losing his magical abilities due to aging and chooses to retire after choosing a successor. He is revealed to be the first human to take up the mantle of Santa Claus after the army of previous Santa Clauses determined that the world needed someone who would be familiar with the development of technology. Liam Seja portrays Calvin as a child during a flashback sequence.
Elizabeth Mitchell as Carol Calvin / Mrs. Claus: Calvin's wife, whom he married during The Santa Clause 2: The Mrs. Clause. Unhappy with her lack of purpose as "Mrs. Claus", Carol is receptive to her husband's decision to retire. Finding success once again in her role as a school principal when they move out of the North Pole, she begins to believe that Calvin's decision was best for the entire family.
Austin Kane as Buddy "Cal" Calvin-Claus, Scott's and Carol's son. Cal at first is excited to experience life in his own way, having become distraught and fearful at the prospect of succeeding his father. Over the course of the series, it is revealed that he possesses magical abilities due to being born in the North Pole and the spirit of Christmas. The character first appeared in The Santa Clause 3: The Escape Clause, where he was named Buddy after his maternal grandfather Bud Newman.
Elizabeth Allen-Dick as Sandra Calvin-Claus: Scott and Carol's daughter and youngest child. Sandra enjoys living at the North Pole and is hesitant to move away when her father decides to retire. She often develops close friendships with animals. Over the course of the series, it is revealed that she has magical abilities that she inherited from Santa Claus and the spirit of Christmas.
Matilda Lawler as Betty (season 1; recurring: season 2): Chief of Staff at the North Pole, and Noel's wife. She later is forced to vacate her position and appoint Noel in her place due to the Kribble Krabble Clause, but returns due to the threat of the Mad Santa.
Devin Bright as Noel: The current right-hand elf at the North Pole, Betty's husband, and one of Santa's best friends. He becomes the new head elf in the second season when Betty goes on Kribble Krabble.
Rupali Redd as Grace Choksi (season 1): Simon's kind-hearted daughter, who believes in the spirit of Christmas. Grace is excited to live at the North Pole and experience the joys of Christmas every day. Her mother expressed desires for the feelings of Christmas every day, prior to passing from a major illness.
Kal Penn as Simon Choksi / Santa Claus (season 1): The man that Scott Calvin chooses to be his successor as Santa Claus at the North Pole. Prior to his new role, Choski is a game inventor, product developer, and single father with aspirations to become the equivalent of "the next Jeff Bezos" in the technology world. When he is appointed as the next Santa Claus, he views the efficiency at the North Pole as an opportunity to realize his unsuccessful business aspirations. Leading in his new role forcefully, Simon determines that every day will be Christmas, providing the world with instant gratification through a combination of his business technology and the North Pole's magic. Over time, however, he becomes disillusioned and bitter with his new role, and indifferent to the survival of the North Pole. As the spirit of Christmas begins to fade, Choksi finds himself at odds with Calvin who returns to reclaim his role as Santa Claus.
Gabriel "Fluffy" Iglesias as Kris Moreno / Kris Kringle (season 2), the head of failing theme park Santapolis who accidentally frees Magnus Antas. He is later revealed to be the kid, now all grown-up, that Scott delivered a kayak to during his first night as Santa.
Eric Stonestreet as Magnus Antas / The Mad Santa (season 2), a rogue past Santa Claus who was overthrown by the elves and imprisoned in a nutcracker by La Befana. Accidentally freed by Kris, Magnus works with him and uses his magic to revitalize Santapolis while seeking to take over the North Pole and become the one true Santa.
