Recurring characters
Nadine Velazquez as Sofia Ruxin, Ruxin's Latina wife. She has a close friendship with Taco, which Ruxin cannot stand. She dies while undergoing vaginal rejuvenation in Puerto Rico.
Jason Mantzoukas as Rafi, Sofia's deranged, obnoxious brother, aka "Bro-lo el Cuñado." Best friend and possible lover of porn director Dirty Randy. He shared a bed with Sofia until she was 18. He was an altar boy as a child, but had to quit after he raped a priest. He always calls Pete "Tall Guy" and believes Kevin's name is Brian. His residence has a large number of "load-bearing chairs" stacked up and has a "toilet-kitchen." Rafi stores a never-ending supply of hotdogs in his pants, referring to them as "pocket dogs." He is a diabetic. He gets "murder boners" when practicing his MMA skills and gets a "war boner" when playing paintball. He thinks that he is Baby Geoffrey's true father. Occasionally he has suggested that he and Sofia shared an incestuous relationship in the past (not directly denied by Sofia). Many times when he vomits, he defecates; many times when he defecates, he orgasms. Ruxin's sarcasm led him to take on the role of Bobbum Man in real life. He is apparently killed by Dirty Randy in a duel. In Season 6's "When Rafi Met Randy," it is revealed Rafi was once a normal family man until Randy's business partner fell to his death on top of Rafi's wife and two sons, killing them all. After numerous suicide attempts, Rafi was checked into a mental asylum along with Randy. An overzealous nurse subjected them both to shock therapy that would alter their minds and result in their current deranged states. Immediately after Randy revealed that he was responsible for the deaths of Rafi's family, Rafi was subjected to a partial lobotomy that made him forget them completely. It is also revealed how Rafi was returned to life via special means.
Alina Foley as Ellie MacArthur, Jenny and Kevin's young daughter. She has inherited her parents' profane language, which got her in trouble with her first grade teacher, Ms. Martin.
Janina Gavankar as Shivakamini Somakandarkram, a doctor who was the valedictorian of most of the League members' graduating high school class. She is a urologist, specializing in genital reconstruction. She usually appears on season finales, as she's the "patron deity" of the League's trophy. They each present an item to the trophy, which contains a high school photo of her. The only odd episode out is "The High School Reunion" when she was present with the league, revealing in the process that Pete's mother's windshield was not busted by a high school friend but rather by Kevin when he lost his virginity to Shiva. Shiva cursed the 2012 season of the League because they would not take her picture off the trophy. She also dated Andre towards the end of Season 1.
Adam Karchmer as Geoffrey Ruxin, Ruxin and Sofia's son. Ruxin calls him "Baby Geoffrey."
Rob Huebel as Dr. Russell Deramo, a friend of the gang. He first appears in "The Draft," where he attends Andre's party. He returns in "The Kluneberg," where it is revealed that he moved to New York but recently returned, saying New York was too crowded and too full of "crazy people." He later reveals that he is a sex addict and invites Jenny to join his league. He later replaces her with Rafi, allowing her to join the League. In Season 5, he is a member of Rafi's Domination League with Dirty Randy. He is introduced into the League in Season 6 as a replacement for Ted, claiming his sex addiction is gone due to his passion for wine. He opens a wine bar known as Ménage a Cinq with Andre, but the business fails when his sex addiction relapses.
Leslie Bibb as Meegan Eckhart, Pete's abrasive ex-wife. They fought constantly. After she gave away his lucky draft shirt, Pete realized that they were not meant to be together and they separated. They finalized the divorce, and she was left with only the house. She had requested their The Curious Case of Benjamin Button DVD, presumably knowing that it contained a disc with a sex video she had made with Pete, but Pete had already snuck into her house and stolen it, aided by Kevin; Pete never gives it back. She was later seen dating an older man named Ted. She returns in Season 7, where it is revealed that she is now dating Andre, whom she later marries.
Seth Rogen as Dirty Randy – Rafi's friend who works as a librarian and a pornographer. He works at the library for the infrastructure and says "it's a place where you can find desperate people and you can pay them in drugs and alcohol to work as part of the porn production team." Before he was a porn director he was homeless, kicked out of the military, a crack dealer, and a porn location scout. He met Rafi in an asylum, an experience he describes as "very romantic." He believes that puns "are as vital to the porn business as they are to the pet shop and children's barbershop industries." He directed such movies as the controversial "Shitler's List" (the controversy was that it was shot in black and white), "Toe-Bangers 3" (the SEAL Team Six member who shot Osama bin Laden found a copy of it in the compound, but the Government will not release the footage), "Dr. Andre Nodick," and "12.12.12: The Mayan Cockandlips" (filmed in the loft Deion Sanders bought from Andre). In Season 5, he is also a member of Rafi's "Domination League." He threatens Ruxin with a trident made from dildos. In Season 6's "When Rafi Met Randy," Randy is revealed to have been a successful businessman who accidentally knocked his partner off a construction building where the man crushed the family of a then-normal Rafi. The two were committed to the same mental institution where numerous shock therapy sessions resulted in their deranged states. When Randy realized he was responsible for the death of Rafi's family, he used another shock session to induce him to forget about them.
Brie Larson as Ashley, Baby Geoffrey's former au pair who was hired due to her good looks. Pete quickly begins sleeping with her, which causes her to neglect her au pair duties. Ruxin wants to fire her, but she extorts him by threatening to tell Sofia that he was masturbating to her photo (he was actually wiping pee off his pants) unless he continues to pay her for doing nothing. To get her to quit, Ruxin enlisted Rafi to hit on her, which ends up backfiring when she brings Rafi into bed with her and Pete to do the "Golden Gate Bridge." Rafi eventually talks her into quitting her job and "moving in" with him at Ruxin's home.
Ike Barinholtz as Frank "The Body" Gibiatti – Ruxin's high school rival. His sister Gina "dated" Pete for a while. The Body gave (and still gives) the guys a hard time.
Jayma Mays as Trixie – Andre's former interior decorator and then fiancée. She is allergic to his semen. She breaks off the engagement after discovering the Secret Draft on her wedding weekend, then blinding herself with Andre's semen-filled pee bib while crying. Taco calls her Pixie instead of Trixie.
Jeff Goldblum as Rupert Ruxin – Rodney's father.
Will Forte as Chuck – One of the League's two out-of-town members, a recovering alcoholic whom they nicknamed "Two-Nut Chuck." In the Season 5 premiere, it is mentioned that he is in rehab again. In the Season 7 premiere, Chuck reveals that he has testicular cancer.
Brooklyn Decker as Gina Gibiatti – Frank Gibiatti's sister who briefly dates Pete and then Adrian Peterson.
Adam Brody as Ted Rappaport – The other out-of-town League member and Season 4 Shiva winner. Ted had AIDS and died after being hit by a car while insulting Kevin via FaceTime.
Jorma Taccone as Spazz – a member of Rafi's Domination League.
June Diane Raphael as Pam, a nurse at the mental institution where Rafi was committed; the actress appears in a different episode as Ellie's teacher.
Zach Woods as Lane, a suicidal acquaintance of Pete's.
Rob Riggle as Bethesda. Partner at Ruxin's firm and coach of Geoffrey's Little League baseball team.
