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Carla Gugino as Verna, a mysterious woman from the Usher twins' past, who takes on various forms, most notably that of a raven, to prey on the Ushers. Verna is an anagram for raven.
Bruce Greenwood and Zach Gilford as Roderick Usher, Madeline's brother and the corrupt CEO of Fortunato Pharmaceuticals. He is based on the character of same name in "The Fall of the House of Usher", while the company is named after a character in "The Cask of Amontillado". Greenwood portrays Roderick in 2023, while Gilford portrays him in 1979.
Graham Verchere as a teenaged Roderick Usher
Lincoln Russo as a child Roderick Usher
Mary McDonnell and Willa Fitzgerald as Madeline Usher, Roderick's sister and the ambitious COO of Fortunato Pharmaceuticals, with a lifelong interest in technological advancements. She is based on the character of same name in "The Fall of the House of Usher". McDonnell portrays the character in 2023, while Fitzgerald portrays her in 1979.
Lulu Wilson as a teenaged Madeline Usher
Kate Whiddington as a child Madeline Usher
Henry Thomas as Frederick Usher, Roderick's eldest son and heir to Fortunato, husband to Morella, and father to Lenore. His name comes from the protagonist of "Metzengerstein".
William Kosovic as kid Frederick Usher
Kate Siegel as Camille L'Espanaye, one of Roderick's illegitimate children, and the sharp-tongued public relations head of Fortunato, obsessed with collecting and controlling information. Her name comes from a character in "The Murders in the Rue Morgue".
Rahul Kohli as Napoleon "Leo" Usher, one of Roderick's illegitimate children, and a prominent video game publisher with a drug addiction. His name comes from a character in "The Spectacles".
Samantha Sloyan as Tamerlane Usher, Roderick's eldest daughter, and an aspiring entrepreneur working on Goldbug, a brand mixing health products, beauty products, and lifestyle advice. Her name comes from the poem "Tamerlane", while the brand’s name comes from the short story “The Gold-Bug”.
T'Nia Miller as Victorine LaFourcade, the eldest of Roderick's illegitimate children, and a gifted surgeon hoping for a breakthrough on an experimental heart device. Her name comes from a character in "The Premature Burial".
Michael Trucco as Rufus Griswold, the former CEO of Fortunato who held the position after Longfellow and before Roderick. The character shares his name with Rufus Wilmot Griswold, a real-life rival of Poe.
Katie Parker as Annabel Lee, Roderick's first wife and mother of Frederick and Tamerlane. Her name comes from the poem "Annabel Lee".
Sauriyan Sapkota as Prospero "Perry" Usher, the youngest of Roderick's illegitimate children, who pursues a hedonistic lifestyle. His name comes from a character in "The Masque of the Red Death".
Matt Biedel as William "Bill-T" Wilson, a fitness influencer, and Tamerlane's husband. His name comes from "William Wilson".
Crystal Balint as Morella Usher, a former model and actress, Frederick's wife, and Lenore's mother. Her name comes from the character in "Morella".
Ruth Codd as Juno Usher, Roderick's second, much-younger wife. She is a former drug addict, now addicted to Ligodone, a Fortunato Pharmaceuticals medication.
Kyliegh Curran as Lenore Usher, Frederick and Morella's daughter. Roderick considers her to be "the best of the Ushers". Lenore is a female character that "died so young" in several of Poe's poems, most notably "Lenore" and "The Raven," believed to be a reference to his wife Virginia, who died of tuberculosis, aged 24.
Carl Lumbly as Charles Auguste Dupin, the Assistant United States Attorney who wants to bring the Ushers to justice. His name comes from the character C. Auguste Dupin, who appears in several of Poe's short stories.
Malcolm Goodwin portrays Dupin in 1979.
Mark Hamill as Arthur Gordon Pym, the family's attorney and fixer, nicknamed "The Pym Reaper" for his ruthlessness and efficiency. His name comes from the novel The Narrative of Arthur Gordon Pym of Nantucket, which serves as the character's backstory.
