Guest
Sunil Hall as Sunil, a cargo ship captain associated with Dr. Lullah.
David Sebastian Williams as the Narrator Fish, a metafictional mutant fish who likes to narrate about different things.
Erica Jones as Rianne, a mutant common warthog and shopkeeper who befriends Chip; she hosts a cooking show in "PANTelevision".
Fred Tatasciore as:
Snake Mutant, a mutant snake.
Keanu Mutant.
Nils Vulfen, a survivalist who refuses help.
Jean-Michel, a raccoon and one of the few non-mutated beings on the island.
Glands, a mucus-spewing Z.O.R.B.Z. (Zorbular Orb Rorb Borb Zorbs).
Kaitlyn Robrock as Tara, a bottlenose dolphin and Merian's adoptive sister.
Fryda Wolff as Merian's mother.
Johnny Pemberton as Peanut, a mutant betta.
Eric Bauza as:
Bomb Swapper, a villain who swaps objects with bombs.
Big Mitchell, a mutant elephant seal.
Catapult Kevin, a mutant bass who hosts a catapult-based TV show.
Grim Reaper, the personification of death.
Arfthur, a known safety mascot.
Cyrina Fiallo as Mariana Trent, a fish counter operator; her name references the Mariana Trench.
Grey DeLisle as:
Flamingo Mutant, a mutant flamingo.
Elephant Triumvirate narrator.
Marieve Herington as:
Zora, a mutant great horned owl.
Crabecca, a mutant hermit crab.
Bee Mutants, a group of mutant bees.
Kayvan Novak as Thurstavius "Thurst" Brinkman Throop, a "mummified" naturalist.
H. Michael Croner as Bakey Potatie, a chimpanzee who becomes cosmically enhanced after being launched into space.
Debra Wilson as Agent, an operative of KROM.
Fortune Feimster as Scrumptious, a mutant hermit crab.
Rama Vallury as Colonel John Stoneman, writer of the Elephant Triumvirate series, abducted by Dr. Lullah.
Josh Brener as Bombo, a mutant frog with disproportionately large legs.
Robin Atkin Downes as Gunch, a mutant kookaburra.
Tru Valentino as Zarconium, a member of the Crystal Delegates.
Stephen Root as Dr. Rostrum, an anthropomorphic octopus-like mad scientist and rival of Dr. Lullah, member of S.T.U.G.O. (Secret Technological Unconventional Genius Organization).
