Post-Yanukovych presidency
From November 2013, protests against Yanukovych's rule evolved into the largest democratic mass movement in Europe since 1989, known as Euromaidan which led to the Revolution of Dignity. Two main goals of Euromaidan were the removal of President Yanukovych and the calling of snap elections. In late January 2014, the party's symbol and activities were banned in the Chernivtsi, Ternopil, and Ivano-Frankivsk regions, although there was no legal basis for these bans, since in Ukraine only a court can ban the activities of a political force. The Party of Regions faction in Zhytomyr announced its dissolution on 19 February 2014.
On 22 February 2014, the Ukrainian parliament voted for the resolution on self-removal of Viktor Yanukovych, as President of Ukraine. Out of the 38 PoR deputies present, 36 voted in favor of ousting Yanukovych, while two did not take part in the vote. Simultaneously, both Yanukovych and former Prime Minister Mykola Azarov fled to Russia. In a written statement the next day, the party denounced Yanukovych, stating they "strongly condemn the criminal orders that led to human victims, an empty state treasury, huge debts, shame before the eyes of the Ukrainian people and the entire world." On 24 February 2014, faction leader Oleksandr Yefremov declared that the party was moving into the opposition. 77 of its MPs had left the faction in the preceding days. On 25 February 2014, Anatoliy Kinakh and 32 other mostly former PoR deputies created the parliamentary faction Economic Development.
On 28 March 2014, Yanukovych asked the Party of Regions to exclude him. The next day, at a party congress, the party nominated Mykhailo Dobkin as its presidential candidate for the 2014 Ukrainian presidential election. The congress expelled many former leaders from the party including Yanukovych, Azarov, former First Deputy Prime Minister Serhiy Arbuzov, ex-chairman of the Ministry of Revenue and Duties Olexander Klimenko, former Energy Minister Eduard Stavitskyi, ex-governor of the Donetsk region Andrew Shishatskiy, and Valery Konovalyuk. On 7 April 2014, the political council of the party also expelled Sergiy Tigipko, Oleh Tsariov, and Yuriy Boiko from the party.
Mykhailo Dobkin was the Party of Regions' candidate in the snap presidential election of 25 May 2014, and received only 3 percent of the vote.
On 3 June 2014, another twenty Party of Regions deputies left the party's parliamentary faction. Including this change, the faction's strength was reduced from 210 deputies (at its highest point on 12 December 2012) to 80 deputies by 6 June 2014. As a result, it became the second biggest faction in parliament after the 85 member-strong Batkivshchyna faction. On 2 July 2014, the 32 member-strong new parliamentary faction For Peace and Stability, composed mostly of former Party of Regions MPs, was formed. In the following months many former members of the Party of Regions became objects of the so-called "trash bucket challenge", where Ukrainian officials dumped images of the former PoR members into garbage bins and other trash containers.
On September 17, 2014, amidst the ongoing war in Donbas, a group of 24 people's deputies of Ukraine from the Party of Regions and the Communist Party of Ukraine met with Sergey Naryshkin, the chairman of the Russian State Duma. On September 25, 2014, the Central Investigation Administration of the Ukrainian Ministry of Internal Affairs opened a criminal case against those deputies, charging them with infringement on the territorial integrity of Ukraine.
The Ukrainian press claimed that during the days around the February 2014 Ukrainian revolution, several party members called for the disintegration of Ukraine and for a union with the Russian Federation. News outlets claimed that Oleksandr Yefremov, leader of the Ukrainian parliamentary faction, was in full support of these proposed actions, and that Vladimir Konstantinov, chairman of the Supreme Council of the Autonomous Republic of Crimea went to Luhansk to support these actions.
On 14 September 2014, the Party of Regions officially announced their choice not to participate in the 2014 parliamentary elections; the party deemed the election as lacking legitimacy because the residents of the Donbas could not vote in the election. Many individual members of Party of Regions ended up as candidates of the Opposition Bloc. As of 2026, the Party of Regions has not participated in elections since the 2012 Ukrainian parliamentary election.
By the summer of 2015, most representatives of the party in 2014 had become members of Opposition Bloc, Revival or Our Land. Others continued their political careers in other parties (mostly Petro Poroshenko Bloc). According to Ukrainian media research from February 2016, 22% of the Petro Poroshenko Bloc representatives in regional councils and 12% of the party's parliamentary deputies were former members of the Party of Regions. In the 2020 local elections, former Party of Regions members ran mainly as candidates of the Opposition Platform — For Life, Opposition Bloc, Kernes Bloc — Successful Kharkiv, Trust Deeds and Servant of the People parties.
Following the 2014 annexation of Crimea by Russia and Vladimir Konstantinov's announcement that the Party of Regions Crimean branch would be reorganized, many of its members joined the United Russia party. Officially — according to the TASS news agency and Konstantinov — there is no succession of the United Russia Crimean branch from the Party of Regions Crimean branch, but according to several local news resources from Sevastopol, the transfer was in fact organized by former activists of the Party of Regions and Russian Unity.
As of July 2019, the Party of Regions' former website redirected to “Golos Pravdy”, a pro-Russia blog website which the Atlantic Council considers to be linked to Fancy Bear and which is run by politicians that fled Ukraine in 2014.
After the Russian invasion of Ukraine in 2022, many former members of the Party of Regions supported the Russian side. A number of city leaders in Russian-occupied territories were accused of collaboration and high treason for their cooperation with the Armed Forces of the Russian Federation. For instance, Galina Danilchenko, a deputy in Melitopol who was part of the Party of Regions and the Opposition Bloc, was proclaimed by the Russians as “acting mayor of the city” on 12 March 2022 with support from the Russian army. The mayor of Melitopol, Ivan Fedorov, had been arrested by the Russian military the previous day. In Kupiansk, mayor Gennady Matsegora of the Opposition Platform — For Life party voluntarily surrendered the city to the Russian armed forces. Many former members of the Party of Regions on the ground were also appointed by Russian troops as heads of civil administrations in the occupied territories.
On 21 February 2023, the Eighth Administrative Court of Appeal banned the Party of Regions. This ban was initiated by the Ministry of Justice and the Security Service of Ukraine. Because of the Russo-Ukrainian War (leading to loss of Ukrainian government control in parts of the country), no local elections have been held in some areas since the 2010 Ukrainian local elections; as such, the Party of Regions deputies in those territories still have their mandate.
