2010s
In July 2010, Spencer appeared with Steve Carell, and Paul Rudd in the comedy Dinner for Schmucks. In August 2011, she joined Viola Davis, Emma Stone and Bryce Dallas Howard in the period drama film The Help, an adaptation of the novel of the same name. She played the feisty and unflappable maid Minny Jackson. The film was written, produced and directed by Tate Taylor, and produced by Brunson Green, Chris Columbus, Michael Barnathan, and Mark Radcliffe. She won the 2012 Golden Globe Award for Best Supporting Actress – Motion Picture for her work in The Help. On February 12, 2012, Spencer won a BAFTA for Best Supporting Actress for her Performance in The Help, and on February 26 she won the Academy Award for Best Supporting Actress for the same performance; it was her first Oscar nomination and first win. Spencer was given a standing ovation at the ceremony, and was moved to tears during her acceptance speech. In June 2012, Spencer was invited to join the Academy of Motion Picture Arts and Sciences.
In 2013, she appeared alongside Michael B. Jordan in Fruitvale Station, a film chronicling the last day of Oscar Grant, who was killed at a Bay Area Rapid Transit station in 2009. In September 2013, it was announced that she would reunite with The Help director Taylor in the biopic on singer James Brown Get On Up, opposite her The Help co-star Viola Davis. The film was released in 2014. From September 2014 until February 2015, she starred in Steven Spielberg's Fox drama television series Red Band Society.
Spencer co-starred alongside Kevin Costner in the drama film Black or White (2014) and co-starred as Johanna Reyes in the second installment of the Divergent series, The Divergent Series: Insurgent (2015). She reprised the role in The Divergent Series: Allegiant (2016). She voiced Mrs. Otterton in Disney's Zootopia (2016), which marked her animated film debut.
In 2016, she starred alongside Taraji P. Henson and Janelle Monáe in Hidden Figures, a film about African-American mathematicians at NASA who were critical to its success in the 1960s in the Space Race, and who each had careers there. She played mathematician and human computer Dorothy Vaughan. The role garnered her a Golden Globe Award and Screen Actors Guild Award for her performance and earned Spencer a second nomination for the Academy Award for Best Supporting Actress, making her the first black actress to follow up an Oscar victory with another nomination, having previously won for The Help. In honor of Martin Luther King Jr. Day, Spencer bought out a Los Angeles screening of Hidden Figures to treat low-income families that would have been unable to afford to see the film otherwise.
In 2017, Spencer starred in the Christian drama film The Shack and the family drama film Gifted. She co-starred with Sally Hawkins in Guillermo del Toro's dark fantasy drama film The Shape of Water, which follows a mute custodian at a high-security government laboratory who befriends a captured humanoid-amphibian creature. The film was screened in the main competition section of the 74th Venice International Film Festival, where it premiered to positive reviews on August 31, 2017, and was awarded the Golden Lion for best film in the competition. It also screened at the 2017 Toronto International Film Festival. Spencer earned Golden Globe and BAFTA Award nominations for her portrayal, while receiving her third Academy Award nomination in the Best Supporting Actress category, making her the first black actress to receive two consecutive Oscar nods in back-to-back years.
In 2018, Spencer has starring roles as a preschool principal in the drama film A Kid Like Jake and a social worker in the comedy film Instant Family. She also executive produced the biographical comedy-drama film Green Book, which went on to receive the Academy Award for Best Picture.
In 2019, she starred as Harriet Wilson, a history teacher who makes an alarming discovery about an all-star student, in the drama film Luce. The film premiered at the 2019 Sundance Film Festival and earned critical acclaim. She then received praise for her starring role as Sue Ann "Ma" Ellington in the psychological horror film Ma, which was directed by frequent collaborator Tate Taylor. For the latter, she received a nomination for the Saturn Award for Best Actress. Also in 2019, Spencer returned to television by executive producing and starring in the Apple TV+ drama series Truth Be Told.