2022
On April 25, 2022, the 49ers picked up the fifth-year option on Bosa's rookie contract.
During the season-opener against the Bears, Bosa had five tackles and a sack in the 19–10 road loss. In the next game against the Seahawks, he recorded four tackles and sacked Geno Smith twice during the 27–7 road victory. The following week against the Denver Broncos on Sunday Night Football, Bosa had two tackles and sacked Russell Wilson once in the narrow 11–10 road loss.
During Week 4 against the Rams on Monday Night Football, Bosa had three tackles and two sacks in the 24–9 victory. He missed the Week 6 matchup due to a groin injury he suffered in the previous game against the Panthers. Bosa returned in Week 7 against the Chiefs, recording four tackles and a sack during the 44–23 loss. The following week against the Rams, Bosa had four tackles and sacked Matthew Stafford 1.5 times in the 31–14 road victory.
Following a Week 9 bye, the 49ers returned home to face the Los Angeles Chargers on Sunday Night Football. Bosa finished the 22–16 victory with four tackles and a sack. In the next game against the Cardinals at Estadio Azteca in Mexico on Monday Night Football, Bosa recorded three tackles and a sack during the 38–10 victory. The following week against the Saints, he had three tackles and a sack in the 13–0 shutout road victory. Bosa was named NFC Defensive Player of the Month for the month of November after recording five tackles for a loss, three sacks, and 10 quarterback hits, with the 49ers going 3–0 during that span.
During Week 13 against the Miami Dolphins, Bosa recorded three tackles (two for a loss), a forced fumble, and sacked Tua Tagovailoa thrice in the 33–17 victory. Bosa was named NFC Defensive Player of the Week for his performance. Two weeks later against the Seahawks on Thursday Night Football, Bosa had two tackles, a pass deflection, and a sack in the 21–13 road victory. In the next game against the Washington Commanders, he recorded seven tackles, a forced fumble, and sacked Taylor Heinicke twice during the 37–20 victory. Bosa earned his second NFC Defensive Player of the Week award of the season for his performance. During the regular-season finale against the Cardinals, Bosa had two tackles and sacked David Blough once in the 38–13 victory.
Bosa finished the 2022 season with 51 combined tackles (41 solo), a league-leading 18.5 sacks, two forced fumbles, and a pass deflection in 16 games and starts. He was named as a Pro Bowler for the third time. Bosa was also named as first team All-Pro for the first time. The 49ers finished atop the NFC West with a 13–4 record and qualified for the playoffs as the #2-seed. During the Wild Card Round against the Seahawks, Bosa had five tackles and a fumble recovery in the 41–23 victory. In the Divisional Round against the Cowboys, he recorded two tackles during the 19–12 victory. During the NFC Championship Game against the Eagles, Bosa had four tackles in the 31–7 road loss. At the end of the season, Bosa was named NFL Defensive Player of the Year and The Sporting News Defensive Player of the Year. He was ranked fourth by his fellow players on the NFL Top 100 Players of 2023.
