Recurring
Sendhil Ramamurthy as Mohan Vishwakumar, Devi's deceased father, who appears in flashbacks and visions
Niecy Nash as Dr. Jamie Ryan, Devi's therapist
Eddie Liu as Steve (season 1), Kamala's secret boyfriend.
Christina Kartchner as Eve Hjelm (seasons 1–2; guest season 3), Fabiola's love interest who later moves away
Alexandra Billings as Jennifer Warner (seasons 2, 4), the school's college counselor
Benjamin Norris as Trent Harrison, core member of the Hot Pocket, Paxton's best friend, and later Eleanor's boyfriend
Dino Petrera as Jonah Sharpe (seasons 1–3), a boy who comes out as gay and helps Fabiola with her sexuality
Tembi Locke as Elise Torres (season 1, guest seasons 2, 4), Fabiola's mother
Jae Suh Park as Joyce Wong (season 1; guest season 4), Eleanor's absent mother who is a bumbling actress prioritizing her non-existent career over her daughter
Adam Shapiro as Mr. Lyle Shapiro, a history teacher who tries to relate with his students and be the 'cool' teacher
Cocoa Brown as Principal Grubbs who is often tired with Devi and Ben's rivalry
Martin Martinez as Oliver Martinez (season 1–2), Eleanor's boyfriend and later ex-boyfriend
Jack Seavor McDonald as Eric Perkins, an unpopular student and member of the robotics team who later trains for the swim team with Paxton in season 4
Lily D. Moore as Rebecca Hall-Yoshida (seasons 1–3), Paxton's sister who is interested in fashion design, Paxton is very protective of her as she has down-syndrome and is targeted by bullies. She and Devi develop a friendship
Hanna Stein as Shira Liedman (seasons 1–3), a popular, shallow student and Ben's girlfriend in season 1 using him for his money
Angela Kinsey as Vivian Gross (season 1), Ben's mother who is barely around, prioritizing retreats and herself over her son
Michael Badalucco as Howard Gross (seasons 1, 3), Ben's father who is a big-time entertainment lawyer who like his mother is also an absent parent
Donna Pieroni as Patty (seasons 1, 3), Ben's housekeeper who is more of a parent to Ben than his own
Dana G. Vaughns as Marcus Jones, Paxton's friend (seasons 1–3)
Aitana Rinab as Zoe Maytag, Shira's friend (seasons 1–3)
Megan Suri as Aneesa Qureshi (seasons 2–4), a new Indian student at Sherman Oaks and Devi's new acquaintance and Ben's girlfriend for a brief period. While Devi and her family are Hindu, Aneesa is a Muslim
Rushi Kota as Prashant (season 1–2), an engineer Kamala is set up with by their families. Prashant and Kamala like each other and date briefly until Kamala realises she is not ready to settle down just yet
Tyler Alvarez as Malcolm Stone (season 2), a former Disney actor and an elementary school friend who transfers to Sherman Oaks briefly dating Eleanor
Utkarsh Ambudkar as Mr. Manish Kulkarni (seasons 2–4), an English teacher who is friends with Devi and also coaches the girls' soccer team, later dating Kamala and moving with her when she gets a job offer in season 4.
P. J. Byrne as Evan Safstrom (season 2), a head research assistant at Caltech
John Mawson as Dr. Elgin Peters (season 2), a Nobel prize-winning scientist at Caltech
Common as Dr. Chris Jackson (season 2), a dermatologist who works with Nalini and develops an interest in Nalini
Tohoru Masamune as Kevin Hall-Yoshida (seasons 2–3), Paxton's father
Kelly Sullivan as June Hall-Yoshida (seasons 2–4), Paxton's mother
Ranjita Chakravarty as Nirmala Vishwakumar, Mohan's mother (seasons 2–4), Nalini's mother-in-law and Devi's paternal grandmother who moves in with them in season 2
Clyde Kusatsu as Ted Yoshida (season 2), Paxton's paternal grandfather
Helen Hong as Sharon Wong (season 2), Eleanor's stepmother
Sarayu Blue as Rhyah (season 3), Nalini's new Indian friend and mother to Des
Victoria Moroles as Margot Ramos (seasons 3–4), an artistic student at Sherman Oaks High School who dates Ben and has a rivalry with Devi
Anirudh Pisharody as Nirdesh "Des" (season 3), an Indian student who goes to an elite private school; Rhyah's son and briefly Devi's boyfriend
Michael Cimino as Ethan Morales (season 4), a rebellious high-school senior whom Devi briefly dates
Jeff Garlin as Len (season 4), a man who begins a relationship with Nirmala and later marries her in the season 4 finale
Ivan Hernandez as Andres Ramos (season 4), Margot's single father who works as a contractor in Nalini's home and becomes her love interest
Genneya Walton as Lindsay Thompson (season 4), a new AP Literature substitute teacher at Sherman Oaks High School who later dates Paxton