2019–2020: Career breakthrough and Cuz I Love You
In 2019, in addition to her musical projects, Lizzo ventured into acting, with a voice performance in the animated film UglyDolls, and a supporting part in the crime comedy-drama film Hustlers. "Juice", the lead single from her third studio album, was released on January 4, 2019, by Atlantic Records. The next month, she announced the title of the album, Cuz I Love You, which was eventually released on April 19, 2019. After the release of her album, she performed at the Coachella Music Festival for the first time. The release of Cuz I Love You marked a turning point in Lizzo's career, as she began to attract more mainstream attention; the album debuted at number six on the Billboard 200 and eventually peaked at number four on the chart, three months after its initial release.
After inspiring an internet meme on the TikTok video sharing app and being featured in the 2019 Netflix film Someone Great, Lizzo's 2017 single "Truth Hurts" began to gain popularity and was added to the deluxe version of Cuz I Love You. The single became a viral sleeper hit, and, in turn, increased interest for Cuz I Love You, which remained in the top 10 of the Billboard 200 for several months.
"Truth Hurts" has since become Lizzo's first number-one hit on the Billboard Hot 100. Lizzo became the third female rapper to top the Hot 100 without a featured artist. She also became the first black solo female R&B singer to claim the top spot on the Hot 100 since Rihanna's 2012 hit "Diamonds". A week later, on September 9, 2019, Cuz I Love You became certified gold by the RIAA with over 500,000 equivalent units sold. "Truth Hurts" spent seven weeks atop the Hot 100, tying for the most weeks at number one for a rap song by a female artist. The music video for the song, in which Lizzo "marries herself", has amassed more than 220 million views on YouTube. In an interview, she revealed that the initial lack of success for "Truth Hurts"—what she had thought to be her best song yet at the time—caused her to seriously consider quitting the music industry altogether.
Lizzo is also well known for her ability to play the flute. She began playing as a child, and has continued to improve her flute playing skills into adulthood. She has performed with her flute, which she has named Sasha Flute, in several of her musical performances, including when she performed "Truth Hurts" at the 2019 BET Awards. Her performance at the BET Awards earned her a standing ovation from the crowd, which included Rihanna. Throughout the summer of 2019, Lizzo frequently performed, including on the West Holts stage at the Glastonbury Festival, and as a headliner at the Indianapolis and Sacramento pride festivals.
On July 23, 2019, Lizzo was nominated for Push Artist of the Year and Best New Artist at the 2019 MTV Video Music Awards. She performed a medley of "Truth Hurts" and "Good as Hell" at the 2019 MTV Video Music Awards; her performance received critical praise. Around this time, her 2016 single "Good as Hell" also climbed the charts around the world, reaching the top three of the Billboard Hot 100 and the top ten of the UK Singles Chart. The song also reached the top ten in Australia and Belgium.
Lizzo made her Saturday Night Live debut as a musical guest on the December 21, 2019, episode, which Eddie Murphy hosted. The episode was the final episode of both the year and the decade. In January 2020, Lizzo headlined FOMO Festival, performing in four Australian cities and Auckland, New Zealand. She also performed a sold-out show at the Sydney Opera House, where she had previously performed as a young flute player. She opened the 62nd Annual Grammy Awards with a medley of "Cuz I Love You" and "Truth Hurts", and won three awards at the ceremony. She received eleven nominations at the 2020 Billboard Music Award, winning one for Top Song Sales Artist. At the 2020 BET Awards, she became the first act to be nominated in both the R&B/pop and hip-hop artist categories in the same year. In August 2020, Lizzo signed a production deal with Amazon Studios to develop new projects with them. Her first project was an unscripted reality competition series called Lizzo's Watch Out for the Big Grrrls. The show premiered on March 24, 2022.