Film and television appearances
In 1989, Loeb appeared in the low-budget comedy horror anthology film Tabloid, in a segment entitled "Killer Vacuum Destroys Town". The film was shot in and around Fort Worth, Texas.
Loeb shared title billing with then-boyfriend Dweezil Zappa on the reality show Dweezil & Lisa, which premiered on Food Network on January 16, 2004. The series showed the two musicians touring the country together and sampling unique and diverse dishes. In the opening for each episode, Loeb announced she was a vegetarian who enjoyed eating an occasional piece of bacon.
In the fall and winter of 2005, following her breakup with Zappa, Loeb taped a reality show called #1 Single, which premiered in January 2006 on the E! Channel in New York City. The show dealt with her quest for love, success, career, and family. A re-recording of Loeb's selection "Single Me Out" was used as the program's theme.
Loeb has made several guest appearances on television shows such as The Nanny in 1997, and Cupid the following year. In September 1999, she made an appearance on the comedy show MADtv, singing the theme song for a WB drama sketch called "Pretty White Kids with Problems". In 2007, Loeb appeared on an episode of Jack's Big Music Show singing the song "Jenny Jenkins". In 2008, she made a guest appearance on Gossip Girl, followed by a cameo on an episode of The Sarah Silverman Program in which the cast formed a mock band called "The Loeb Trotters". On the final episode of Gossip Girl on Monday, December 17, 2012, Lisa ended up with the character Rufus Humphrey in the five years after glimpse.
In addition to television shows, Loeb has also appeared in the horror films House on Haunted Hill (1999), Serial Killing 4 Dummys (1999), and Fright Night (2011). She has done voice work including the voice of Mary Jane Watson for the animated show Spider-Man: The New Animated Series, broadcast on MTV. Loeb also voiced the character of Lutina in the video game Grandia Xtreme and characters for The Rugrats Movie and Shorty McShorts' Shorts. As of 2012, Loeb provided the voice of Princess Winger on the Disney Junior animated series Jake and the Never Land Pirates.
In 2008, Loeb was one of the contributors to Carrie Borzillo-Vrenna's book Cherry Bomb; she gave advice on how to be the perfect hostess.
In 2010, Loeb provided guest voices for Disney's Special Agent Oso. In 2012, she provided voice over talent for BonTon industries in their spring TV spots. In December 2012, Loeb made a brief cameo as Matthew Settle's (Rufus Humphrey) love interest in "New York, I Love You XOXO", the final episode of Gossip Girl.
In February 2013, Loeb also made a cameo in an episode of Workaholics where her song "Stay (I Missed You)" is referenced several times. In January 2014, Loeb appeared on the cover of Making Music. In April 2014, Loeb appeared in the first episode of Last Week Tonight with John Oliver in a short musical sketch about Oregon's health care website failure.
In 2015, Loeb appeared as Julie, lead singer of the fictitious band "Natalie is Freezing", in the episode "Advanced Safety Features" of the TV series Community. She also appeared as herself in Hot Tub Time Machine 2. Other shows she has recently been involved in include Orange Is the New Black, About a Boy, King of the Nerds, Sunny Side Up Show, and Fuller House.
In 2021, Loeb appeared in a GEICO commercial campaign singing her hit “Stay” setup as an audition.
In 2024, Loeb made a guest star appearance in That 90s Show playing herself in a daydream had by the main character, Leia, of Loeb's music video, “Stay”.