2018–present: Acting activities and solo debut with The First Scene
In 2018, Yuri was cast in the second season of the sitcom, The Sound of Your Heart as the female lead, which premiered its first season on Netflix on October 29. In January, she released a collaboration single titled "Always Find You" with DJ Raiden. She was also cast in MBC's upcoming drama Dae Jang Geum Is Watching, which premiered in October.
In August 2018, Yuri was announced to be part of Girls' Generation's second sub-group, Oh!GG, which consisted of the five members who remained under SM Entertainment; the group released their first single, "Lil' Touch", in September.
Yuri released her six-track debut EP, The First Scene, on October 4, 2018, with the lead single "Into You". The album debuted at number two on the Gaon Album Chart and charted at number 10 on Billboard's World Albums chart in its first week with only one day to garner points to enter it. Yuri performed "Into You" on South Korea's music shows and her promotions for the album allowed her to top the Brand Reputation rankings for individual girl group members published by the Korean Corporate Reputation Research Institute for the month of October.
Starting in November, Yuri appeared in the Channel A variety show, Makgeolli on the Rooftop, during which she and other celebrities learned how to brew makgeolli, a traditional Korean rice wine. In January 2019, she was cast in her first stage play, Grandpa Henry and Me ("L'Étudiante et Monsieur Henri"), which is a Korean version of the 2012 French play by Ivan Calbérac.
On August 26, 2020, Yuri joined Bossam: Steal the Fate as the female lead. The drama ended by recording an average viewership of 9.8% nationwide in its last episode, therefore becoming MBN's highest viewership rating for a drama in history.
On May 1, 2021, Hyoyeon and Yuri make an appearance on tvN's Amazing Saturday.
In September 2021, Kwon was confirmed to join the independent film Dolphin, making a comeback to the big screen since 2015. Her performance in this film earned her a Best New Actress nomination at the 45th Blue Dragon Film Awards.
On December 12, 2023 the production team of the movie Somebody announced the cast lineup including Kwak Sun Young, Girls' Generation's Yuri, Lee Seol, Ki So You, and more. On May 14, 2024 the movie was showcased at the 2024 Cannes Film Festival Market. Somebody, produced by Studio Santa Clause Entertainment was released in 2024.
On January 13, 2026 it was confirmed that Yuri will return to the theater after six years with the psychological thriller play The Wasp.
In July 2026, SM Entertainment announced that Yuri's exclusive contract with the agency would end on August 31. The agency stated that she would remain a member of Girls' Generation.