Saturday Night Live
McKinnon joined the cast of Saturday Night Live as a featured player on April 7, 2012, following a March 28, 2012 report of her being hired. She was promoted to repertory status in season 39 in 2013.
In 2013, McKinnon was nominated for an Emmy Award for Best Supporting Actress, Comedy. McKinnon won the 2014 American Comedy Award for Best Supporting Actress, TV for her work on SNL. In 2014, she was nominated for an Emmy Award for Outstanding Supporting Actress in a Comedy Series, as well as for Outstanding Original Music and Lyrics along with four of her colleagues for the song "(Do It On My) Twin Bed." She was nominated for an Emmy for Outstanding Supporting Actress in a Comedy Series for the second time in 2015. She won the following year, becoming the first actor from SNL to win the award since Dana Carvey in 1993.
McKinnon began appearing as Hillary Clinton on the series leading up to the 2016 presidential election. The real Clinton appeared alongside her in a sketch during the show's season 41 premiere. McKinnon has said that her impression of Hillary Clinton comes from a deep admiration, and that she "unequivocally want[ed] her to win" the 2016 presidential election. On November 12, 2016, which was the first show after Clinton's loss in the election, she reprised the role to open the show with a solo performance of "Hallelujah" by Leonard Cohen, whose death was announced two days before her performance. After the election, McKinnon began to impersonate Kellyanne Conway alongside Alec Baldwin as Donald Trump. On February 11, 2017, she debuted her impression of Elizabeth Warren during Weekend Update and Jeff Sessions in the cold open.
McKinnon is known for her character work and celebrity impressions of pop singer Justin Bieber, comedian television host Ellen DeGeneres, and numerous political figures, including US Attorney General Jeff Sessions, Senator Lindsey Graham, Supreme Court Justice Ruth Bader Ginsburg, Clinton, Warren, Robert Mueller, Angela Merkel, and Rudy Giuliani. She has been nominated for seven Primetime Emmy Awards, including one for Outstanding Original Music and Lyrics and six for Outstanding Supporting Actress in a Comedy Series, winning in 2016 and 2017.
McKinnon's return to season 46 made her the show's longest tenured female cast member, surpassing her cast mates Cecily Strong and Aidy Bryant by five episodes. Bryant and McKinnon left the series after season 47. They had both originally planned on leaving at the end of the 45th season in 2020, but the COVID-19 pandemic changed their plans and they left at the end of season 47 in 2022. Strong passed McKinnon's record with the December 17, 2022 episode of season 48.
Olya Povlatsky, a Russian woman who voices her opinions on current events, comparing them to the outrageous struggles she faces in her village. She also appeared in a cold open with Beck Bennett as Vladimir Putin reading a prepared statement against her will.
Sheila Sovage, a heavily intoxicated woman at a bar who meets and hooks up with a heavily intoxicated man or woman, played by the host, at closing time.
Jodi Cork, The Art of the Encounter and Women in the Workplace co-host with Donna Fingerneck (played by Cecily Strong).
Barbara DeDrew, a lesbian volunteer at the cat shelter Whiskers R We.
Deenie, a.k.a. "Somebody's Mom," a middle-aged woman who attempts to recap shows she's been watching, but only knows the characters by self-applied nicknames, such as "Big Boobs" and "Mustache." She is always eating some foul concoction out of Tupperware, such as Brussels sprouts and imitation crab, which generally revolts Weekend Update anchor Colin Jost.
Mrs. Santini, an apartment dweller who writes passive-aggressive notes to her neighbors. Originally performed as Effie Villalopolus on Comedy Bang! Bang!
Colleen Rafferty, a 27-year old woman (despite looking middle-aged, implicitly due to her repeated traumas) who appears on panels with two friends. They recount their experience of a shared paranormal event, such as being abducted by aliens. The other two friends always have an idyllic experience, while Rafferty instead experiences significant trauma.
Les Dykawitz, a lesbian cop from the 1970s who works for the Chicago Police Department along with her partner Chubina Fatzarelli (played by Aidy Bryant) in "Dyke & Fats."
Debette Goldry, a senile elderly actress whose harsh experiences with being an actress in old Hollywood are more outrageous than what modern actresses have gone through.
A member of Woodbridge High School's theatre troupe that performs solely about social justice issues they know very little about.
Noelle LeSoup, the co-host of the French show "America's Funniest Cats" who appears on the American version of the show along with Joelle LaRue (played by Cecily Strong).
Shud, a crass mermaid who is based on a blobfish, and makes sexual advances on an unfortunate marooned sailor.
Dr. Wayne Wenowdis, a strangely accented middle-aged medical doctor, who debuted in 2020, as part of the Weekend Update segment with Colin Jost.
Madame Vivelda, a fortune teller who predicts people's 2020 experiences.