Film director (2005–2019)
Anand turned a film director with Kana Kandaen (2005), a thriller film starring Prithviraj Sukumaran, Srikanth and Gopika. The film opened to favourable reviews from critics, with a reviewer from Rediff.com noting "Anand has succeeded in making an extremely watchable, highly thrilling film with a 'different' story". Despite the success of the film, Anand opted to return to cinematography to fulfil commitments for Rajinikanth's Sivaji (2007) directed by Shankar, which became the most expensive Tamil film ever made at the time.
Anand then collaborated with AVM Productions and Suriya in Ayan (2009), an action entertainer set on the backdrop of the Indo-African drug smuggling trade. In order to prepare the script, Anand did a lot of research and is said to have spoken to a lot of custom officers to understand the modus operandi of smuggling. The film opened in April 2009 to positive reviews, and became one of the year's highest-grossing Tamil language films. A critic from Rediff.com called the film a "must-watch" adding "what gets you by surprise is the thread of logic that laces practically every encounter, and the way Anand's screenplay covers all the angles". A reviewer from Sify.com stated "Anand pushes the commercial cinematic envelope and brings a savvy freshness in treatment and packaging hitherto unexplored in Ayan".
His third directorial venture, Ko (2011), narrated the tale of photojournalists caught up in a political corruption scandal. Starring Jiiva, Ajmal Ameer, Karthika Nair and Piaa Bajpai, the film also received a positive from film critics and the box office. A reviewer from The Hindu described the film as a "tale with a realistic twist" and mentioned that Anand "strikes gold with Ko". The critic added "blending the commercial with the realistic is a challenge, but Anand proves adept at it." Likewise, The Times of India noted "With Ko, director Anand gives notice of his immense talent once again, making a movie that is all set to lord over the box office this summer".
Anand worked with Suriya again in Maattrraan (2012), and was inspired to make the film after watching a documentary about the conjoined twins Chang and Eng Bunker. While preparing the script, he worked closely with a team of doctors to ensure the medical condition of open-heart transplant, as shown in the film, could be showcased as realistically as possible. He later made a mythical thriller film, Anegan (2015) starring Dhanush, and another political thriller film, Kavan (2017), with Vijay Sethupathi. His final film Kaappaan (2019), starring Mohanlal, Suriya and Arya told the tale of a Special Protection Group (SPG) officer who protects the Prime Minister.