Second marriage
Secondly he married Elizabeth Wrottesley (died 10 May 1558), a daughter of Walter Wrottesley (died 1563) of Wrottesley Hall, Staffordshire by his wife Elizabeth Harcourt. They had four sons and four daughters, including:
Sir John Talbot (died 9 December 1581), lord of the manor of Salwarpe, Worcestershire. He married 13 September 1574 Olive Sherrington, daughter of Sir Henry Sherrington of Lacock, Wiltshire, and had four children:
Sherrington Talbot (died c. 1642) of Salwarpe, Worcestershire. He married firstly Elizabeth Leighton, daughter of Sir Thomas Leighton of Feckenham, Worcestershire, Governor of Jersey and Governor of Guernsey, and Elizabeth Knollys (born 1549), and had two sons, and married secondly Mary Washbourne, daughter of John Washbourne of Wichinford, Worcestershire, and had two sons:
Sherrington (or Sheringham) Talbot (died c. 1677), married 13 October 1627 Jane Lyttelton, sister of Sir Thomas Lyttelton, 1st Baronet, and had one son:
Sir John Talbot of Laycock, Keighley, Yorkshire. He married Barbara Slingsby, daughter of Sir Henry Slingsby, 1st Baronet, and had two daughters:
Anne Talbot
Barbara Talbot (c. 1671 - 31 January 1763). She married 11 July 1689 Henry Yelverton, 1st Viscount de Longueville
Sir Gilbert Talbot (died unmarried)
William Talbot (died 27 March 1686), of Stourton Castle, Staffordshire. He married Mary Doughty (died c. 1661), daughter of Thomas Doughty of Kinver, Staffordshire, and of Whittington, Staffordshire, and had three children:
Frances Talbot
Catherine Talbot
William Talbot, Bishop of Durham
George Talbot of Rudge, Shropshire, married and had one daughter:
Catherine Talbot
Thomas Talbot of Worvill, Shropshire. He married Magdalen Wyvill, daughter of Sir Marmaduke Wyvill, and had one son:
Robert Talbot of Worvill, Shropshire. He married Anne Sheldon, daughter of William Sheldon of Broadway, Worcestershire, and had three sons:
George Talbot
Thomas Talbot of Worvill, Shropshire
Gilbert Talbot
John Talbot (born between 1575 and 1581), of Badgworth, Somerset. He married Mary Trimnel, daughter of Thomas Trimnel of Okeley, Worcestershire, and had one son:
John Talbot (born after 1591), of Okeley, Worcestershire