Biography
The first verse of the Book of Isaiah states that Isaiah prophesied during the reigns of Uzziah (or Azariah), Jotham, Ahaz, and Hezekiah, the kings of Judah. Uzziah's reign was 52 years in the middle of the 8th century BC, and Isaiah must have begun his ministry a few years before Uzziah's death, probably in the 740s BC. He may have been contemporary with Manasseh for some years. Thus, Isaiah may have prophesied for as long as 64 years.
According to some modern interpretations, Isaiah's wife was called "the prophetess", either because she was endowed with the prophetic gift, like Deborah and Huldah, or simply because she was the "wife of the prophet". They had two sons, naming the elder Shear-Jashub, meaning "A remnant shall return", and the younger Maher-Shalal-Hash-Baz, meaning, "Quickly to spoils, plunder speedily." According to the Jewish interpretation of Isaiah 7:14 the two also had a son named Immanuel, a verse interpreted by Christians as prophesizing the virgin birth of Jesus.
Soon after this, Shalmaneser V determined to subdue the northern Kingdom of Israel, taking over and destroying Samaria and beginning the Assyrian captivity. So long as Ahaz reigned, the kingdom of Judah was untouched by the Assyrian power. But when Hezekiah gained the throne, he was encouraged to rebel "against the king of Assyria", and entered into an alliance with the king of Egypt. The king of Assyria threatened the king of Judah, and at length invaded the land. Sennacherib's campaign in the Levant brought his powerful army into Judah. Hezekiah was reduced to despair, and submitted to the Assyrians. But after a brief interval, war broke out again. Again Sennacherib led an army into Judah, one detachment of which threatened Jerusalem. Isaiah on that occasion encouraged Hezekiah to resist the Assyrians, whereupon Sennacherib sent a threatening letter to Hezekiah, which he "spread before the LORD".
Then Isaiah son of Amoz sent this message to Hezekiah: "Thus said GOD, the God of Israel, to whom you have prayed, concerning King Sennacherib of Assyria—
this is the word that GOD has spoken concerning him:
Fair Maiden Zion despises you,
She mocks at you;
Fair Jerusalem shakes
Her head at you.
Whom have you blasphemed and reviled?
Against whom made loud your voice
And haughtily raised your eyes?
Against the Holy One of Israel!
According to the account in 2 Kings 19 (and its derivative account in 2 Chronicles 32) an angel of God fell on the Assyrian army and slew 185,000 of its men in one night. "Like Xerxes in Greece, Sennacherib never recovered from the shock of the disaster in Judah. He made no more expeditions against either Judea or Egypt."
The remaining years of Hezekiah's reign were peaceful. Isaiah probably lived to its close, and possibly into the reign of Manasseh. The time and manner of his death are not specified in either the Hebrew Bible (Tanakh) or other primary sources. The Talmud says that he suffered martyrdom by being sawn in two under the orders of Manasseh.
The book of Isaiah, and the book of the prophet Jeremiah, are distinctive in the Hebrew Bible for their direct portrayal of the "wrath of the LORD" as presented, for example, in Isaiah 9:19 stating "Through the wrath of the LORD of hosts is the land darkened, and the people shall be as the fuel of the fire."