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Luke Kleintank as Scott Forrester (seasons 1–3), an FBI Supervisory Special Agent and Head of the International Fly Team. Near the end of the third season, he leaves the team and the Bureau to reunite with his fugitive mother, with the two disappearing shortly afterwards.
Heida Reed as Jamie Kellett (seasons 1–3), an FBI Special Agent who is the team's second in command. She later resigns from the team in the third season premiere, having fulfilled many things on her list, while also revealing she's returning to the United States and joining the Washington, D.C. field office.
Carter Redwood as Andre Raines, an FBI Special Agent on the team, with a background in accounting.
Vinessa Vidotto as Cameron Vo, an FBI Special Agent; she is a West Point graduate and is the team's newest member (until the addition of special agent Amanda Tate). In season 3, she is made second-in-command of the Fly Team following Kellett's departure.
Christiane Paul as Katrin Jaeger (season 1; guest seasons 2 & 4), a multilingual Europol agent from Germany who acts as a liaison for the team, until her promotion to the head of Europol at the end of the first season.
Eva-Jane Willis as Megan "Smitty" Garretson (seasons 2–4), a Europol agent and old acquaintance of Forrester assigned to replace Jaeger as the team's liaison.
Christina Wolfe as Amanda Tate (seasons 3–4), an FBI Supervisory Intelligence Analyst brought on to lead the Fly Team's new analyst team.
Green as Tank, a black Giant Schnauzer trained in Schutzhund and retired cadaver dog that obeys Scott Forrester's commands and is adopted by Andre Raines.
Jesse Lee Soffer as Wesley "Wes" Mitchell (season 4), a former L.A.P.D. officer who is the new Supervisory Special Agent and Head of the International Fly Team following Forrester's departure.
