Manchester United
As a result of Barthez's success in the World Cup and the Euros, he caught the attention of Manchester United manager Sir Alex Ferguson, who was searching for a star goalkeeper to replace the recently departed Peter Schmeichel, as Ferguson did not think that the previous season's goalkeeper, Mark Bosnich, was a long-term replacement. Barthez joined United for £7.8 million in 2000. He was later reunited with national teammate Laurent Blanc, who joined United in 2001. The Barthez–Blanc head-kissing ritual was performed at the start of Champions League matches.
Known eccentric, Barthez started out well for Manchester United. In his first season he answered all the questions about how he would handle rainy Manchester compared to sunny Monaco. Barthez quickly became a crowd favourite. The fans loved his eccentric behaviour, his taunting dribbles and step-overs past opposing strikers, and his reaction saves. Very often, it was critical saves that kept United from defeat or dropping valuable points, helping United to the 2000–01 FA Premier League title, their third in a row.
A memorable incident happened when Manchester United faced Leeds United in March 2001. After dropping a cross from Robbie Keane, Barthez deliberately kicked out with his foot at Ian Harte, who fell to the ground on the edge of six yard box, and the referee awarded a penalty to Leeds. Harte stepped up but Barthez made a low, one-handed save to his right. The only blemish in his first season was his failed attempt at "psyching out" West Ham United's Paolo Di Canio in the FA Cup Fourth Round; Di Canio beat the offside trap, while Barthez stood still with his hand up expecting the referee to blow his whistle, or Di Canio to stop. Di Canio continued and scored the only goal of the game, and later said it was "better to score and then see whether the goalkeeper is right or wrong".
The 2001–02 season was split into two parts for him. The first half was tumultuous. The Frenchman seemed to be taking some unnecessary risks outside his penalty area, and his antics began to have consequences that allowed unneeded goals for opposing teams. He was at fault for two goals in a 3–2 home defeat by Deportivo de La Coruña in October 2001. Ferguson said how "eventually he will get caught out" and it wouldn't happen again. But another couple of late errors against Arsenal in a 3–1 defeat at Highbury the following month put much pressure on Barthez, with two goals gifted to Thierry Henry, one of which came from a mis-hit clearance. Barthez was at the centre of further controversy when, after already being on a yellow card following an argument with Matthew Upson, he was caught by television cameras raising his middle fingers behind his back towards the Arsenal supporters, who had been taunting him for his errors towards the end of the match; the incident was missed by the referee Peter Jones, however. There was much speculation as to what was the source of Barthez's decline, and critics such as the BBC's Phil McNulty urged him to be dropped. Sir Alex Ferguson, however, had faith in his goalkeeper, and stuck by him. Consequently, in the second half of the season, Barthez repaired his reputation with consistent, solid performances and the spectacular saves that he was famous for. His turn in fortunes was shown in a 2–2 draw with Derby County at Pride Park. Derby forward Malcolm Christie looked to have sealed his hat-trick, but referee Steve Dunn controversially disallowed the goal, ruling that Christie kicked the ball out of Barthez's hands.
He was also noted for playing mind games before opposition players took a penalty. The first time this occurred was in November 2001 when Leicester City came to Old Trafford. As Muzzy Izzet prepared to take a penalty, Barthez stood aside from the goal, with his hands behind him on the post. Izzet, tired of waiting, slotted the ball in the bottom corner, but referee Andy D'Urso made him retake the penalty, this time with Barthez in goal. Izzet went the same way, but Barthez denied him with a fine save to his right. An almost identical incident happened less than a year later in October 2002, when Barthez was unhappy about the awarding of a penalty to Fulham, and so went from post to post banging his boots, and refused to be in goal for the penalty. This time he was booked for his antics by referee Mike Dean, and so he then took his place between the posts and made it work again by saving Steed Malbranque's spot kick.
The 2002–03 season ended with another Premier League crown for United. The season was a mixed bag for Barthez. One highlight was a fabulous save to deny Dietmar Hamann's 30-yard rocket at Anfield against Liverpool, as United held on to win 2–1. In other games, he let goals go past him that he would have been expected to save, and suffered from a run of poor form towards the end of the season. Barthez was also widely criticized in United's exit to Real Madrid in the Champions League, especially for Ronaldo's opener which beat him at the near post. It would prove to be his last ever game with United as Sir Alex Ferguson's patience had finally run out. Barthez was dropped for the final three games of the season, with Roy Carroll taking his place.
Barthez's poor form at the end of the previous season and the arrival of American newcomer Tim Howard in summer of 2003, saw the Frenchman face competition for a starting spot at United. As Barthez had only returned from international duty in August, Howard played during the club's American tour of the summer, and his performances led Ferguson to choose him to start over Barthez in the Community Shield in August.
By October, Howard had won the starting goalkeeper's job from Barthez; as a result, United agreed to release Barthez from his contract at Old Trafford after the 2003–04 season, and also agreed to loan Barthez out to his former club Marseille for the remainder of that season.