Los Angeles Clippers (2001–2008)
After two successful seasons with the Bulls, Brand was traded to the Los Angeles Clippers in June 2001 for Brian Skinner and the draft rights to Tyson Chandler. In 2002, Brand became the first Clipper since Danny Manning (in 1994) to be selected to the All-Star team.
When Brand became a restricted free agent in 2003, the Miami Heat made an offer worth $82 million over six years. In what was an unprecedented move by team owner Donald Sterling, the Clippers matched Miami's offer and managed to keep Brand a Clipper. Prior to this, the biggest contract Sterling had approved to that point was a five-year, $15 million deal for Eric Piatkowski in 1998. Sterling had also refused to offer Brand a contract extension one year prior, when he was willing to accept less than the maximum.
In the 2006 NBA season, Brand experienced a professional renaissance. He posted career-highs in points per game (24.7) and field-goal percentage (52.7), while leading the Clippers to a 47–35 record, their then-best record in team history, and good enough for the sixth seed in the Western Conference. Brand was selected to the 2006 NBA All-Star Game and considered as a strong candidate for the 2006 NBA MVP. Brand led the franchise to its first playoff series win since 1976, when the team was known as the Buffalo Braves. Although the Clippers eventually lost in Game 7 of the second round (Western Conference Semifinals) against the Phoenix Suns, the Clippers had the best season that their franchise had ever seen at that time. Brand received the Joe Dumars Trophy after being named the 2005–06 NBA Sportsmanship Award winner.
Following his stellar 2005–06 season, Brand regressed somewhat in the following season. His scoring average in 2006–07 dropped and the Clippers missed the playoffs.
He missed most of the 2007–08 season due to a ruptured left Achilles tendon. However, Brand made his return to the Clippers' lineup April 2, 2008 after being out since the end of the previous season. He contributed 19 points in his return. Brand played in only eight games that season. Brand later opted out of the final year of his contract and became a free agent. Sources indicated that Brand chose to opt out from his contract in order to provide Clippers with more payroll flexibility in hopes of strengthening their roster. This came to fruition when Clippers landed Golden State Warriors star Baron Davis. Briefly, this gave Clippers' management and the media the reassurance that Brand would indeed re-sign with the team.