2010–present
In 2010, he returned to the Saw franchise in Saw 3D (2010), the seventh film in the series, as Dr. Lawrence Gordon. In 2010, he returned to Psych, reprising his role in the second half of the fifth season, again in the show's sixth season, and again in the show's eighth season premiere. In 2014, Elwes played Hugh Ashmeade, Director of the CIA, in the second season of the BYU TV series Granite Flats. In 2011, he was selected by Ivan Reitman to star alongside Natalie Portman in No Strings Attached. That same year, Elwes and Garry Marshall teamed up again in the ensemble romantic comedy New Year's Eve opposite Robert De Niro and Halle Berry.
In 2012, Elwes starred in the independent drama The Citizen. and the following year Elwes joined Selena Gomez for the comedy ensemble, Behaving Badly directed by Tim Garrick. In 2015, he completed Sugar Mountain directed by Richard Gray; the drama We Don't Belong Here, opposite Anton Yelchin and Catherine Keener directed by Peer Pedersen, and Being Charlie which reunited Elwes with director Rob Reiner after 28 years and premiered at the Toronto International Film Festival. In 2016, Elwes starred opposite Penélope Cruz in Fernando Trueba's Spanish-language period pic The Queen of Spain, a sequel to Trueba's 1998 drama The Girl of Your Dreams. This also re-united Elwes with his Princess Bride co-star, Mandy Patinkin.
In October 2014 Touchstone (Simon & Schuster) published Elwes's memoir of the making of The Princess Bride, entitled As You Wish: Inconceivable Tales from the Making of The Princess Bride, which he co-wrote with Joe Layden. The book featured never-before-told stories, exclusive behind-the-scenes photographs, and interviews with co-stars Robin Wright, Wallace Shawn, Billy Crystal, Christopher Guest, Fred Savage and Mandy Patinkin, as well as screenwriter William Goldman, producer Norman Lear, and director Rob Reiner. The book debuted on The New York Times Best Seller list.
In 2014, Elwes co-wrote the screenplay for a film entitled Elvis & Nixon, about the pair's famous meeting at the White House in 1970. The film starred Michael Shannon and Kevin Spacey; it was bought by Amazon as their first theatrical feature and released on 22 April 2016. In May 2015, Elwes was cast as Arthur Davenport, a shrewd and eccentric world-class collector of illegal art and antiquities in Crackle's first streaming network series drama, The Art of More, which explored the cutthroat world of premium auction houses. The series debuted on 19 November and was picked up for a second season.
In April 2018 Elwes portrayed Larry Kline, mayor of Hawkins, for the third season of the Netflix series Stranger Things, which premiered in July 2019. He was nominated along with the cast for the Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Drama Series. In May 2019, he joined the third season of the Amazon series The Marvelous Mrs. Maisel as Gavin Hawk.