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Three of the four girls (Jo, Meg, and Amy) are named after the March sisters in the novel Little Women.
Jo (ジョウ, Jō)
Voiced by: Akeno Watanabe (Japanese); Monica Rial (English)
Jo serves as the group's primary combatant and pilot of Django, using it to execute missions for Sei and assist allies—particularly Meg, whom she prioritizes above all else. Throughout the series, romantic undertones suggest her feelings for Meg. Outside combat, she enjoys horror and gore films. Her backstory reveals she was a genetically engineered weapon, later rediscovering her origins. After being captured and reprogrammed at Hinode, she escapes during a confrontation with her counterpart Maria, who seeks to prove their superiority. Their climactic battle exhausts both fighters, ultimately restoring Maria's humanity. Determined to end RAPT, Jo defies Meg's protests, renders her unconscious for safety, and departs after leaving her jacket as a memento.
ADR Director Christopher Bevins comments that Jo is "like a female cross between Clint Eastwood and Wolverine".
Meg (メグ, Megu)
Voiced by: Megumi Toyoguchi (Japanese); Jamie Marchi (English)
Meg is characterized by her red hair (initially depicted as black in the monochrome episode "Wild Kids") and distinctive cowgirl attire, typically armed with a revolver and occasionally an anti-tank rifle. Frequently captured during missions, she relies on Jo for rescue, demonstrating unwavering loyalty to her. Their partnership began when Jo encountered Meg as an orphan in New York City, leading them to become bounty hunters. While the anime portrays their bond with subtle affection, the manga explicitly depicts Meg's romantic attraction to Jo, including sexual fantasies and overt advances. After learning of Jo's engineered origins, Meg opposes her continued combat role—prompting Jo to incapacitate her and leave her jacket as a farewell. In the finale, Meg discovers Jo's scarf at RAPT's ruins and bids her goodbye, later appearing in Jo's outfit with an Orange Django, mirroring the series' opening sequence.
In the Newtype magazine article, Meg is the "'spunky act now, ask questions later' gal" and that voice actor Jamie Marchi "brilliantly captured Meg's What-ever attitude".
Sei (セイ)
Voiced by: Rie Tanaka (Japanese); Clarine Harp (English)
Sei serves as Bailan's composed leader, recruiting Jo and Meg while donning a distinctive blue jacket and black bun hairstyle. Born into a powerful Chinese syndicate, she received traditional training before inheriting leadership from her grandfather. When clan members allied with RAPT—compromising their values and coercing her cooperation—Sei ultimately rebelled with her grandfather's counsel. Her fate remains unresolved after the RAPT headquarters' destruction, where she and Jo were caught in the explosion.
In the Newtype magazine article, Bevins comments that Sei's character is cold, business-like, and notes that Clarine Harp's personality of sarcastic exterior, but most caring and fiercely loyal interior, "that's Sei to a T".
Amy (エイミー, Eimī)
Voiced by: Mikako Takahashi (Japanese); Alison Retzloff (English)
Amy is a technologically gifted youth recruited by Sei after her hacking activities attracted government scrutiny. Her expertise enabled Bailan to locate and enlist Jo and Meg. Typically seen with light brown pigtails and carrying a pink stuffed animal concealing a laptop, she frequently engages in good-natured arguments with Meg while enjoying Kyohei's snacks.
In the Newtype magazine article, Bevins comments that "while Amy is just as brainy as Conan" (the title character in Case Closed, and also voiced by Retzloff), "she has a prissy, snotty demeanor that would give the young detective a migraine".
