Trump's cabinet nominees, first term
Of Trump's 2017 Secretary of State nominee Rex Tillerson, Schatz said in a statement, "From international human rights to the grave threats facing our country, Mr. Tillerson’s views do not align with well-established, bipartisan foreign policy. The United States has built our global leadership on a foundation of core American values of liberty and justice for all—values that were missing from Mr. Tillerson’s testimony in his nomination hearing. After reviewing his record and his testimony before the Senate, I do not believe Mr. Tillerson is the right person to lead the State Department. I will vote no on his nomination to lead the State Department." Tillerson was confirmed in a 56–43 vote.
Schatz voted to confirm Mike Pompeo as CIA Director in 2017. When Trump nominated Pompeo to succeed Tillerson as Secretary of State in 2018, Schatz said on Twitter (now X), "I voted YES on Pompeo for CIA on the theory that he would be the 'adult in the room.' I was wrong. I am voting NO on Pompeo for Secretary of State because our top diplomat should believe in diplomacy. He has an alarming tendency towards military provocation and brinkmanship." Pompeo was confirmed in a 57–42 vote.
Of Trump's 2017 Secretary of the Treasury nominee Steven Mnuchin, Schatz said in a statement, "Steven Mnuchin has a troubling business record using predatory business tactics. The United States government entrusted his company, OneWest, to help seniors and working families stay in their homes during the housing crisis. His company did the exact opposite, preying on vulnerable homeowners and profiting from it. In addition to his disturbing record, Steven Mnuchin has pledged to roll back the consumer protections that were put into place to stop the kind of reckless practices that caused the financial crisis in 2008. This is dangerous and irresponsible, and that’s why I will be voting no on Steven Mnuchin’s confirmation." Mnuchin was confirmed in a 51–48 vote.
In 2017, Schatz voted to confirm Trump's nominee Jim Mattis as Secretary of Defense. Mattis was confirmed in a 98–1 vote. After Mattis resigned, effective in 2019, Trump nominated Mark Esper for the position. Schatz voted to confirm Esper, who was confirmed in a 90–8 vote.
In 2017, Schatz voted against Trump's Attorney General nominee, Jeff Sessions. He said in a statement, "Throughout Sen. Sessions' career, he has been on the wrong side of history. As a U.S. attorney and in the Senate, he failed to protect fundamental civil rights, including the right to vote. When he had the chance to protect equal rights for LGBTQ Americans and help reform a racially biased and outdated sentencing system, he refused to do so. When the Department of Justice worked to end racial discrimination and the use of excessive force by police, he stood in opposition. And when confronted with the reality of the president's inhumane plan to deport undocumented children who call the United States home, he showed zero empathy. Time and time again, when presented with the opportunity to advocate for the central mission of the Justice Department—pursuing equal justice for all—Sen. Sessions fell short." Sessions was confirmed in a 52–47 vote. After Sessions resigned, Trump nominated William Barr (attorney general under President George H. W. Bush) to the position. Schatz voted against Barr, saying, "Mr. Barr has been clear where he should be vague, and vague where he should be clear". Barr was confirmed in a 54–45 vote.
In 2017, Trump nominated Ryan Zinke for Secretary of the Interior. Schatz voted against his nomination, but he was confirmed in a 67–31 vote. After Zinke resigned, Trump nominated David Bernhardt to the position. Schatz voted against Bernhardt's nomination, but he was confirmed in a 56–41 vote.
Trump nominated Sonny Perdue for Secretary of Agriculture in 2017. Schatz voted to confirm Perdue, and he was confirmed in an 87–11 vote.
Trump nominated Wilbur Ross for Secretary of Commerce in 2017. Schatz voted to confirm Ross, and he was confirmed in a 72–27 vote.
Trump nominated Tom Price for Secretary of Health and Human Services in 2017. Schatz expressed concern about Price's nomination and voted against it. Price was confirmed in a 52–47 vote. After Price's controversial tenure and resignation, Trump nominated Alex Azar to fill the position. Schatz voted against Azar, citing his positions on the Affordable Care Act and the healthcare system. Azar was confirmed in a 55–43 vote.