Toronto Blue Jays (2019–2025)
On July 29, 2019, the Blue Jays selected Bichette's contract and promoted him to the major leagues. On that day, he recorded his first major league hit, a single against Brad Keller of the Kansas City Royals, on the second major league pitch he saw. On July 31, Bichette recorded three hits against the Royals, the second of which was his first MLB home run. On August 6, Bichette became the first MLB player to hit 10 extra base hits in his first nine major league games with a double against the Tampa Bay Rays. After hitting another double on August 7, Bichette joined Yadier Molina and Derrek Lee as the only players in the live-ball era to record a double in eight straight games and broke the Blue Jays franchise record set by Carlos Delgado in 2000. Playing in Toronto for the first time the following day, Bichette extended his doubles streak to nine games, setting a new MLB record. He also set a new MLB record in extra-base hits in the first 11 games of his career with 13. He is the first rookie with 9 straight games with extra-base hits since Ted Williams in 1939. Bichette set franchise records with 20 hits and an 11-game hit streak with a 1.316 OPS during the 11-game span. He finished the season hitting .311 with 11 home runs in 46 games.
Overall with the Jays during the Covid-shortened 2020 season, Bichette batted .301 with five home runs and 23 RBIs in 29 games.
On July 4, 2021, Bichette was named an All-Star for the first time. At the time of his nomination, Bichette had a slash line of .290/.340/.529, with 15 home runs and 54 RBI. Bichette finished the 2021 season batting .298/.343/.484 with 29 home runs, 102 RBIs and 25 stolen bases. He led the American League with 191 hits, while defensively he led the league with 24 errors.
On September 5, 2022, Bichette had a 3-home run game in a game against the Baltimore Orioles. In doing so, he also made history with teammate Vladimir Guerrero Jr., in which they were the first pair of teammates to have a 3-home run game in the same season, and both have fathers who played in MLB. He finished the 2022 season with a .290/.333/.469 slash line, 24 home runs, 93 RBI, and led the majors in foul balls hit, with 587.
Bichette led the American League in hits in both 2021 and 2022, with 191 and 189, respectively. On April 14, 2023, he recorded the 500th hit of his MLB career in his 407th game, surpassing the previous franchise record held by Vernon Wells and Shannon Stewart, who needed 432 games to reach the milestone. In 2023, he batted .306/.339/.475, had 175 hits (4th in the AL), and led AL batters in line drive percentage (27.4%) and percentage of balls hit to the opposite field (40.6%).
In 2024, Bichette batted .225/.277/.322, had 70 hits, 4 HRs, and 31 RBI.
On May 31, 2025, Bichette recorded his 100th home run of his career against the Athletics, becoming the first Blue Jay shortstop to reach the milestone in franchise history.
Bichette injured the posterior cruciate ligament in his left knee on September 6 and missed the rest of the regular season. He returned to the Blue Jays' lineup in the 2025 World Series as the second baseman, his first MLB appearance at the position. He launched a 3-run home run off the Dodgers' pitcher Shohei Ohtani in the 3rd inning of Game 7 of the World Series, but that was not enough, as his team ultimately lost Game 7 and the World Series. Following the World Series, Bichette became a free agent on November 5.