Villain with Present roles
Her career took a different direction in 2006 when she played an anti-heroine role to Sarah Geronimo in the drama series Bituing Walang Ningning, a TV adaptation of a 1980s movie starring Cherie Gil and Sharon Cuneta. Her superb performance as Lavinia Arguelles won her a Best Actress nomination at the 2007 PMPC Star Awards for Television and a Best Actress award in Gawad Amerika. She later appeared as Kristine Hermosa's ambitious twin sister in the afternoon drama Prinsesa ng Banyera.
In 2008, dela Cruz signed up with GMA Network and made a comeback via primetime drama series Babangon Ako't Dudurugin Kita where she played the villain role of Via Fausto. The series gave her the opportunity to work again with her previous co-stars such as Marvin Agustin, Tonton Gutierrez and Dina Bonnevie. Later that year, she was given a role in the afternoon drama series Una Kang Naging Akin, again she is the main antagonist which became a consistent top rater in the ratings game. In October of the year, she was cast as the scheming ex-girlfriend of JC de Vera in the primetime series LaLola.
After giving birth, dela Cruz returned to the screen by playing Iza Calzado's good-hearted sister in the afternoon drama series Kaya Kong Abutin ang Langit. She most recently appeared in the primetime fantasy comedy series Pilyang Kerubin, telefantasya Dwarfina and the sports series Futbolilits. She made a guest appearance on the pilot episode of Ruben Marcelino's Kokak before being cast as one of the leads in the primetime drama series Biritera in which she received positive reviews. After playing a good character in Biritera, she went back to playing villainous roles in the afternoon drama series Kasalanan Bang Ibigin Ka? and in the primetime fantasy series Aso ni San Roque. In 2013, Angelika once again plays the good character as Rodora Santos / Giselle Atienza-Carbonel in Mundo Mo'y Akin followed by Kambal Sirena (2014) and Second Chances (2015) then later she played Nimfa as the villainous mother of her stepson Jay (Kristofer Martin) in Healing Hearts along with Chloe (Krystal Reyes). In 2016, Dela Cruz played Evelyn as Larry's lovable wife and Ana's protagonist mother in Hanggang Makita Kang Muli.
In June 2017, she joined the cast in GMA's hit drama series Ika-6 na Utos as she played the new character, Geneva Ferrer-Takanashi, an older sister of Georgia (played by Ryza Cenon). In that series, she was first seen as a villain but later became good/hero.
In February 2019, she played the role of Lucy Lopez in Inagaw na Bituin as the main antagonist and mother to the anti-heroine, Ariella Lopez who was played by Therese Malvar. She also makes her sister and niece's life miserable in that series.
In January 2022, she comes back to GMA's hit drama series Little Princess as she played the role of Elise Reyes, a loving mother to the main protagonist, Princess Reyes-Montivano who was played by Jo Berry, and the Marcus's (played by Jestoni Alarcon) ex-lover or mistress.
