Liverpool
On 19 July 2018, Liverpool confirmed the signing of Alisson for a fee of £66.8 million (€72.5 million), making him the most expensive goalkeeper of all time. However, the fee was broken just four weeks later when Chelsea signed Kepa Arrizabalaga for a reported £71.6 million (€80 million). On 10 August, Liverpool confirmed via their official website that he would wear the vacant number 13 shirt in the 2018–19 season.
Alisson made his debut for Liverpool on 12 August, keeping a clean sheet in a 4–0 win over West Ham United. He received praise for his subsequent performances in wins over Crystal Palace and Brighton & Hove Albion which saw him keep three consecutive clean sheets. In August, Alisson was shortlisted for UEFA Champions League Goalkeeper of the Season, finishing in second place. However, with Alisson in goal, Liverpool went on a run of 20 games unbeaten in the league from the start of the season which saw the Brazilian break Javier Mascherano's record for the longest-such streak. Alisson also played an important role in Liverpool's Champions League group stage campaign, making a vital save late on in their final group game against Napoli as Liverpool won 1–0 to advance to the knockout stages.
On 4 March 2019, he kept his 17th Premier League clean sheet for the season; the most by any Premier League goalkeeper in his debut season since former Liverpool goalkeeper, Pepe Reina in 2006. At the end of the season, Alisson kept a total of 21 clean sheets in Premier League, and won the Golden Glove. In the Champions League knockout stages, meanwhile, Alisson played a starring role as Liverpool advanced to their second consecutive final in the competition; in their second-leg semi-final at home to Barcelona, he made a number of impressive saves as Liverpool overturned a 3–0 first leg deficit to advance past their opponents with a 4–0 home win. In the final on 1 June 2019, Alisson kept a clean sheet for Liverpool as they defeated Tottenham Hotspur 2–0, making eight saves in the process, to win his first trophy with the club.
After spending his first season with the designated squad number 13, it was announced that Alisson would be wearing the number 1 shirt for the 2019–20 season, which had previously been worn by Loris Karius.
Alisson started in the 2019 FA Community Shield against Manchester City on 4 August; after a 1–1 draw, Manchester City ultimately won the title 5–4 on penalties. On 9 August 2019, in the opening match of the 2019–20 Premier League season against newly promoted Norwich City at Anfield, Alisson picked up a calf injury in the first-half, and had to be replaced by new signing Adrián after 38 minutes. He was expected to be out injured for a "few weeks". As a result, he was ruled out of the 2019 UEFA Super Cup, which Liverpool won 5–4 on penalties on 14 August, following a 2–2 draw with Chelsea after extra-time. He returned to the matchday squad on 20 October, in a 1–1 draw with rivals Manchester United. On 30 November, in a 2–1 win over Brighton & Hove Albion, he was sent off for handling the ball outside his designated area. On 21 December, Alisson kept a clean sheet against Flamengo in the FIFA Club World Cup final with Liverpool winning the trophy for the first time. On 19 January 2020, Alisson assisted Mohamed Salah's 93rd-minute goal, in a 2–0 home win against Manchester United in the league.
On 6 March 2020, Alisson was injured again, meaning he missed the next day's Premier League win against Bournemouth, and the Champions League round of 16 second-leg defeat against Atlético Madrid, the final two Liverpool matches before the season was suspended due to the COVID-19 pandemic. He ended the 2019–20 Premier League with a Premier League winner's medal, having made 29 appearances.
On 20 September 2020, Alisson saved a penalty in Liverpool's second league game of the 2020–21 Premier League season, a 2–0 away win against Chelsea. This was Alisson's first penalty save for Liverpool since joining the club, and Jorginho's first missed penalty in nine attempts for Chelsea in all competitions. On 7 February 2021, Alisson made two errors in the space of three minutes, conceding possession to allow Manchester City's İlkay Gündoğan and Raheem Sterling to score, as Liverpool lost 4–1. On 16 May 2021, Alisson scored a dramatic late winner in a 2–1 victory against West Bromwich Albion. With Liverpool chasing a spot in the top four and the score tied at 1–1, Alisson came up for a Liverpool corner in the 95th minute. The corner, taken by Trent Alexander-Arnold, found Alisson, who managed to score with a header. This was the first goal scored by a keeper in a competitive match in Liverpool's 129-year history, and Alisson became the sixth goalkeeper to score in the Premier League.
On 4 August 2021, prior to the start of the 2021–22 Premier League season, Alisson signed a new contract extension to stay with Liverpool until the summer of 2027. On 15 May 2022, Alisson won the FA Cup with Liverpool, defeating rivals Chelsea 6–5 on penalties in the final. Alisson saved a penalty from Mason Mount, allowing Liverpool's Kostas Tsimikas to score the winning penalty in the shoot-out. Moreover, Alisson earned a runners-up medal in the Champions League as Liverpool lost 1–0 to Real Madrid in the final. Liverpool narrowly missed out on the chance to achieve a historic quadruple, coming second in the Premier League and the 2021–22 UEFA Champions League but winning both the EFL Cup and the FA Cup.
On 16 October 2022, Alisson assisted Mohamed Salah for a late winning goal in Liverpool's 1–0 win over rivals Manchester City in the Premier League. Having already assisted Salah in February of the same year against Norwich City, Alisson became the goalkeeper with the most goal contributions in Premier League history, with 1 goal and 3 assists for Liverpool. Three days later, on 19 October, Alisson saved a penalty from Jarrod Bowen as Liverpool beat West Ham United 1–0 in the Premier League. Alisson was named Liverpool's Player of the Month for October 2022. Alisson reached 100 clean sheets for Liverpool on 6 May 2023 in a 1–0 victory against Brentford. At the end of the 2022–23 season, Liverpool narrowly missed out on UEFA Champions League qualification. Despite this, Alisson was widely praised as one of the best performers in the Premier League that season.
On 27 August 2023, Alisson made an acrobatic save to deny Miguel Almirón from scoring in a 2–1 victory against Newcastle United which would later earn him the Premier League Save of the Month award for August. On 5 October 2024, he went off injured in the 79th minute during the club's 1–0 away win against Crystal Palace sidelining him for two months. He marked his return from injury by keeping a clean sheet in Liverpool's 1–0 away win against Girona in the UEFA Champions League on 10 December 2024.
On 5 March 2025, Alisson delivered a Man of the Match performance against Paris Saint-Germain in the first-leg of the UEFA Champions League Round of 16 tie as he made 9 saves to give Liverpool a clean sheet in a 1–0 away win. However, the club lost the tie in the penalty shoot-out after suffering a 1–0 defeat at Anfield in the second-leg. He eventually secured his second Premier League title with Liverpool at the end of the 2024–25 season.
