President of the People's Party
In March 2022, the 20th National Congress of the People's Party was called to elect a new national party leader after the forced ousting of incumbent Pablo Casado, who had been losing support following a dispute with the President of the Community of Madrid, Isabel Díaz Ayuso. Feijóo put himself forward as a candidate, and was endorsed by regional PP leaders such as Ayuso, Jorge Azcón (Aragon), Alfonso Fernández Mañueco (Castile and León) and Juan Manuel Moreno (Andalusia). He ran unopposed as the only other prospective candidate, a 28-year-old local activist from Valencia, did not have enough verified signatures. He named the party's spokesperson in the Congress of Deputies, Cuca Gamarra, as the party's new Secretary General.
During Feijóo's candidacy, the PP formed a government with Vox in the Cortes of Castile and León. He endorsed the coalition, but said that he would not repeat it on the national level: "sometimes it's better to lose government than win it through populism". As party president, Feijóo halted his predecessor's plans to sell the party headquarters on Calle de Génova.
On 24 May 2022, Feijóo was elected by the Parliament of Galicia as senator for the region, for which he resigned his seat in the Parliament of Galicia. A year later, he led his party in regional and local elections. He attacked prime minister Pedro Sánchez of the PSOE for relying on parliamentary support from EH Bildu, a Basque nationalist party fielding 44 convicted ETA members as candidates, as well as for his government passing legislation on sexual consent that led to offenders having their sentences lowered or quashed.
The PP achieved absolute majorities in the city and Community of Madrid, and took regions including Aragon, the Valencian Community and the Balearic Islands from the PSOE, leading Sánchez to call an early national election. The conservative party secured 137 seats, winning the elections but failing to achieve a parliamentary majority of 176 seats; however, King of
Spain Felipe VI asked Feijóo to try to form government. On 23 August, The Congress of Deputies' Socialist speaker, Francina Armengol, announced that Feijóo's investiture debate would take place on 27 and 29 September. The debate's first vote failed, with 172 MPs voting in favor and 178 against; the second vote took place on 29 September, and it confirmed Feijóo's failure to become prime minister.
Following Feijóo's failure in his investiture vote, Sánchez was voted in as PM as Feijóo and his party summoned Spaniards to the streets in protest against Sánchez's proposed amnesty law for supporters of Catalan independence. After corruption cases rocked Sánchez, in January 2025, Feijóo opened the door to a motion of no confidence against Sánchez with the support of Vox and Junts, a pro-Catalan independence party headed by Carles Puigdemont, having previously refused to speak to Junts. At his party's National Congress on 5 June 2025, Feijóo was reelected as the party's president with 99.24% of the votes. During the event, Feijóo promised to lead the party to a "reformist centre" of the political spectrum in an attempt to attract both left- and right-wing voters, vowing to restore Spain's institutions after 7 years of Socialist rule. However, on 13 July, Feijóo announced that he would be willing to reach agreements with right-wing Vox in exchange for the party's support for a PP minority government, even though he promised he was confident in that the PP would gain an absolute majority in the next elections.
In November 2025, Feijóo led tens of thousands of protesters in Madrid demanding the resignation of Sánchez amid corruption scandals involving former ministers.
